SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing ev...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/7805900 |
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| author | Alena Strýčková Jakub Benko Martin Jozef Péč Monika Péčová Jana Žolková Monika Brunclíková Tomáš Bolek Ján Staško Matej Samoš Marián Mokáň |
| author_facet | Alena Strýčková Jakub Benko Martin Jozef Péč Monika Péčová Jana Žolková Monika Brunclíková Tomáš Bolek Ján Staško Matej Samoš Marián Mokáň |
| author_sort | Alena Strýčková |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients. |
| format | Article |
| id | doaj-art-9b93ec6332e74a32afc4d8247bcb9628 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-9b93ec6332e74a32afc4d8247bcb96282025-02-03T05:57:22ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/7805900SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa InhibitionAlena Strýčková0Jakub Benko1Martin Jozef Péč2Monika Péčová3Jana Žolková4Monika Brunclíková5Tomáš Bolek6Ján Staško7Matej Samoš8Marián Mokáň9National Centre of Hemostasis and ThrombosisDepartment of Internal Medicine IDepartment of Internal Medicine INational Centre of Hemostasis and ThrombosisNational Centre of Hemostasis and ThrombosisNational Centre of Hemostasis and ThrombosisDepartment of Internal Medicine INational Centre of Hemostasis and ThrombosisDepartment of Internal Medicine IDepartment of Internal Medicine ICoronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.http://dx.doi.org/10.1155/2022/7805900 |
| spellingShingle | Alena Strýčková Jakub Benko Martin Jozef Péč Monika Péčová Jana Žolková Monika Brunclíková Tomáš Bolek Ján Staško Matej Samoš Marián Mokáň SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition Case Reports in Hematology |
| title | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
| title_full | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
| title_fullStr | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
| title_full_unstemmed | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
| title_short | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
| title_sort | sars cov 2 infection associated aortic thrombosis treated with oral factor xa inhibition |
| url | http://dx.doi.org/10.1155/2022/7805900 |
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