Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment
Purpose: Melasma is a persistent skin condition caused by excessive melanin production, particularly affecting women’s quality of life. It can result from various factors like sun exposure, genetics, hormones, medications, or inflammation. Effective melasma treatment requires products that can deepl...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2024-12-01
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| Series: | Advanced Pharmaceutical Bulletin |
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| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-14-759.pdf |
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| author | Amiremad Kheirieh Amirhessam Kheirieh Zahra Mahdavi Ali Mohammad Halvani Amir Mohammad Bagheri Hooriyeh Nassirli Shiva Golmohammadzadeh Bizhan Malaekeh-Nikouei |
| author_facet | Amiremad Kheirieh Amirhessam Kheirieh Zahra Mahdavi Ali Mohammad Halvani Amir Mohammad Bagheri Hooriyeh Nassirli Shiva Golmohammadzadeh Bizhan Malaekeh-Nikouei |
| author_sort | Amiremad Kheirieh |
| collection | DOAJ |
| description | Purpose: Melasma is a persistent skin condition caused by excessive melanin production, particularly affecting women’s quality of life. It can result from various factors like sun exposure, genetics, hormones, medications, or inflammation. Effective melasma treatment requires products that can deeply penetrate the skin. The outermost skin layer, known as the stratum corneum (SC), plays a crucial role in delivering topical and transdermal drugs. Researchers have developed numerous strategies to enhance skin permeability and drug efficacy. Methods: This review delves into energy-based techniques and nanocarrier systems for treating melasma, specifically focusing on improving drug delivery to the viable epidermis (EP) while overcoming the SC barrier. Results: Physical methods offer benefits such as enhanced skin penetration but come with drawbacks like frequent visits, high costs, and the need for specialized equipment and skilled operators. Microneedle patches are gaining attention as a convenient physical treatment option for delivering multiple medications effectively, offering targeted delivery and minimal side effects. Nanocarrier systems like transferosomes demonstrate promise in enhancing skin penetration for treating melasma and skin hyperpigmentation. While they offer advantages such as high drug entrapment and improved bioavailability, challenges like stability issues and scalability hinder their widespread adoption. Conclusion: Energy-based techniques enhance drug penetration but can lead to scarring and burns, while dissolvable micro-needles offer a convenient and effective alternative. Nano-drug carriers, like nanostructured lipid carriers (NLCs) and transferosomes, show promise for improved skin drug delivery with their flexible structures and enhanced penetration capabilities, yet further clinical research is needed for definitive conclusions |
| format | Article |
| id | doaj-art-9b921ac0d160486c84f9cc0dcfcaed3d |
| institution | DOAJ |
| issn | 2228-5881 2251-7308 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj-art-9b921ac0d160486c84f9cc0dcfcaed3d2025-08-20T03:02:02ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082024-12-0114475979310.34172/apb.42794apb-42794Energy-Based Methods and Nanocarrier-Based Approaches for Melasma TreatmentAmiremad Kheirieh0Amirhessam Kheirieh1Zahra Mahdavi2Ali Mohammad Halvani3Amir Mohammad Bagheri4Hooriyeh Nassirli5Shiva Golmohammadzadeh6Bizhan Malaekeh-Nikouei7Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Clinical Research Development Unit, Bahar Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Purpose: Melasma is a persistent skin condition caused by excessive melanin production, particularly affecting women’s quality of life. It can result from various factors like sun exposure, genetics, hormones, medications, or inflammation. Effective melasma treatment requires products that can deeply penetrate the skin. The outermost skin layer, known as the stratum corneum (SC), plays a crucial role in delivering topical and transdermal drugs. Researchers have developed numerous strategies to enhance skin permeability and drug efficacy. Methods: This review delves into energy-based techniques and nanocarrier systems for treating melasma, specifically focusing on improving drug delivery to the viable epidermis (EP) while overcoming the SC barrier. Results: Physical methods offer benefits such as enhanced skin penetration but come with drawbacks like frequent visits, high costs, and the need for specialized equipment and skilled operators. Microneedle patches are gaining attention as a convenient physical treatment option for delivering multiple medications effectively, offering targeted delivery and minimal side effects. Nanocarrier systems like transferosomes demonstrate promise in enhancing skin penetration for treating melasma and skin hyperpigmentation. While they offer advantages such as high drug entrapment and improved bioavailability, challenges like stability issues and scalability hinder their widespread adoption. Conclusion: Energy-based techniques enhance drug penetration but can lead to scarring and burns, while dissolvable micro-needles offer a convenient and effective alternative. Nano-drug carriers, like nanostructured lipid carriers (NLCs) and transferosomes, show promise for improved skin drug delivery with their flexible structures and enhanced penetration capabilities, yet further clinical research is needed for definitive conclusionshttps://apb.tbzmed.ac.ir/PDF/apb-14-759.pdfmelasmahyperpigmentationenergy-based methodsnanocarriers |
| spellingShingle | Amiremad Kheirieh Amirhessam Kheirieh Zahra Mahdavi Ali Mohammad Halvani Amir Mohammad Bagheri Hooriyeh Nassirli Shiva Golmohammadzadeh Bizhan Malaekeh-Nikouei Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment Advanced Pharmaceutical Bulletin melasma hyperpigmentation energy-based methods nanocarriers |
| title | Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment |
| title_full | Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment |
| title_fullStr | Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment |
| title_full_unstemmed | Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment |
| title_short | Energy-Based Methods and Nanocarrier-Based Approaches for Melasma Treatment |
| title_sort | energy based methods and nanocarrier based approaches for melasma treatment |
| topic | melasma hyperpigmentation energy-based methods nanocarriers |
| url | https://apb.tbzmed.ac.ir/PDF/apb-14-759.pdf |
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