Leptin induces altered differentiation of keratinocytes by inducing insulin resistance: implications for metabolic syndrome-induced resistance of psoriatic therapy

Leptin induces altered differentiation of keratinocytes by inducing insulin resistance: implications for metabolic syndrome-induced resistance of psoriatic therapy

Background: Psoriatic patients tend to develop metabolic syndrome (MS). MS accelerates psoriasis, but the exact molecular mechanisms are poorly understood.Objectives: We aim to investigate the impact of leptin on keratinocyte insulin sensitivity and explore its underlying molecular mechanism, which...

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Bibliographic Details
Main Authors: Rui Wang, Chongli Yu, Zijie Tang, Jie Sun, Youlin Wang, Zhenkai Zhao, Biwen Lin, Chengxin Li
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Dermatological Treatment
Subjects:
Psoriasis
metabolic syndrome
leptin
keratinocyte
insulin resistance
Online Access:https://www.tandfonline.com/doi/10.1080/09546634.2024.2309305
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