RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW)
The paper presents an overview of the structure and functions of caspase group enzymes. The main stages and ways of development of programmed cell death - apoptosis were demonstrated. The mechanisms of inhibition and activation of caspasesand their role in cell apoptosis are demonstrated. The differ...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/630 |
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| _version_ | 1849696303930408960 |
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| author | E. S. Kokareva V. V. Morozov Ya. M. Stanishevskiy M. A. Zhuravleva A. V. Zubkov |
| author_facet | E. S. Kokareva V. V. Morozov Ya. M. Stanishevskiy M. A. Zhuravleva A. V. Zubkov |
| author_sort | E. S. Kokareva |
| collection | DOAJ |
| description | The paper presents an overview of the structure and functions of caspase group enzymes. The main stages and ways of development of programmed cell death - apoptosis were demonstrated. The mechanisms of inhibition and activation of caspasesand their role in cell apoptosis are demonstrated. The different stages of caspase activation in the body are still insufficiently studied. At present, the structure, properties, key points of the functioning and regulation of caspases in the body have been studied in detail, but at the molecular and cellular levels it is not enough to directly regulate their activity. Modern studies of the effect of artificially created substances of different nature on these enzymes, in turn, open up prospects for further search for methods of their regulation, which in turn would allow using the knowledge gained in the treatment of oncological, autoimmune and neurodegenerative diseases. |
| format | Article |
| id | doaj-art-9b9037005d084c2c9fe52e6f3a95fc2d |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-9b9037005d084c2c9fe52e6f3a95fc2d2025-08-20T03:19:31ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01042936630RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW)E. S. Kokareva0V. V. Morozov1Ya. M. Stanishevskiy2M. A. Zhuravleva3A. V. Zubkov4Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Federal State Budgetary Scientific Institution «Research Institute of Vaccines and Sera, I. I. Mechnikov's» (FSBSI RIVS I. I. Mechnikov's)The paper presents an overview of the structure and functions of caspase group enzymes. The main stages and ways of development of programmed cell death - apoptosis were demonstrated. The mechanisms of inhibition and activation of caspasesand their role in cell apoptosis are demonstrated. The different stages of caspase activation in the body are still insufficiently studied. At present, the structure, properties, key points of the functioning and regulation of caspases in the body have been studied in detail, but at the molecular and cellular levels it is not enough to directly regulate their activity. Modern studies of the effect of artificially created substances of different nature on these enzymes, in turn, open up prospects for further search for methods of their regulation, which in turn would allow using the knowledge gained in the treatment of oncological, autoimmune and neurodegenerative diseases.https://www.pharmjournal.ru/jour/article/view/630apoptosiscaspasenucleotidesnucleotide-peptide substancesprogrammed cell death |
| spellingShingle | E. S. Kokareva V. V. Morozov Ya. M. Stanishevskiy M. A. Zhuravleva A. V. Zubkov RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW) Разработка и регистрация лекарственных средств apoptosis caspase nucleotides nucleotide-peptide substances programmed cell death |
| title | RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW) |
| title_full | RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW) |
| title_fullStr | RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW) |
| title_full_unstemmed | RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW) |
| title_short | RESEARCH ON THE INFLUENCE OF VARIOUS SUBSTANCES ON CASPASE ACTIVITY (REVIEW) |
| title_sort | research on the influence of various substances on caspase activity review |
| topic | apoptosis caspase nucleotides nucleotide-peptide substances programmed cell death |
| url | https://www.pharmjournal.ru/jour/article/view/630 |
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