Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat

Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat

Abstract Background To investigate the frequency of difficult-to-treat (D2T) rheumatoid arthritis (RA) in patients early escalated to biologic/targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs) after failure of treat-to-target with methotrexate (MTX). Methods From a prospective c...

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Main Authors: Bernardo D’Onofrio, Ludovico De Stefano, Emanuele Bozzalla Cassione, Valentina Morandi, Francesca Cuzzocrea, Garifallia Sakellariou, Antonio Manzo, Carlomaurizio Montecucco, Serena Bugatti
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Early
Difficult-to-treat
Refractory
Methotrexate
Treat-to-target
Online Access:https://doi.org/10.1186/s13075-024-03431-5
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