Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature
Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/7169564 |
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| author | Daniela Pirela Daniela Treitl Siba El Hussein Robert Poppiti Thomas Mesko Alex Manzano |
| author_facet | Daniela Pirela Daniela Treitl Siba El Hussein Robert Poppiti Thomas Mesko Alex Manzano |
| author_sort | Daniela Pirela |
| collection | DOAJ |
| description | Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy. As a result, the patient underwent a right thyroid lobectomy and isthmusectomy. Histological sections revealed an intrathyroidal nodule consistent with a clear cell neoplasm of parathyroid origin. The histologic appearance together with the immune profile was diagnostic of WCCA, with diffuse positivity for GATA3, focal weak positivity for parathyroid hormone, and negativity for PAX8, thyroglobulin, TTF1, synaptophysin, chromogranin, and S100p. Our study focuses on the clinical presentation, current management strategies, and review of the available literature surrounding this rare diagnosis. The ultimate goal is to help endocrinologists and surgeons establish a foundational treatment plan for intrathyroidal clear cell tumor cases. |
| format | Article |
| id | doaj-art-9b856a67dea643c49a643518ba337a9e |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-9b856a67dea643c49a643518ba337a9e2025-02-03T01:11:06ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/71695647169564Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of LiteratureDaniela Pirela0Daniela Treitl1Siba El Hussein2Robert Poppiti3Thomas Mesko4Alex Manzano5Mount Sinai Medical Center, Internal Medicine Department, 4300 Alton Road, Miami Beach, FL, USAMount Sinai Medical Center, Surgery Department, Miami Beach, FL, USAMount Sinai Medical Center, Pathology Department, Miami Beach, FL, USAMount Sinai Medical Center, Pathology Department, Miami Beach, FL, USAMount Sinai Medical Center, Surgery Department, Miami Beach, FL, USAThe Thyroid, Parathyroid and Pituitary Center for Miami, Internal Medicine Department, Miami Beach, FL, USAWater-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy. As a result, the patient underwent a right thyroid lobectomy and isthmusectomy. Histological sections revealed an intrathyroidal nodule consistent with a clear cell neoplasm of parathyroid origin. The histologic appearance together with the immune profile was diagnostic of WCCA, with diffuse positivity for GATA3, focal weak positivity for parathyroid hormone, and negativity for PAX8, thyroglobulin, TTF1, synaptophysin, chromogranin, and S100p. Our study focuses on the clinical presentation, current management strategies, and review of the available literature surrounding this rare diagnosis. The ultimate goal is to help endocrinologists and surgeons establish a foundational treatment plan for intrathyroidal clear cell tumor cases.http://dx.doi.org/10.1155/2016/7169564 |
| spellingShingle | Daniela Pirela Daniela Treitl Siba El Hussein Robert Poppiti Thomas Mesko Alex Manzano Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature Case Reports in Pathology |
| title | Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature |
| title_full | Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature |
| title_fullStr | Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature |
| title_full_unstemmed | Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature |
| title_short | Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature |
| title_sort | intrathyroidal clear cell tumor of parathyroid origin with review of literature |
| url | http://dx.doi.org/10.1155/2016/7169564 |
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