Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report
Abstract Since the first reported case of monkeypox in the UK in May 2022, there has been an upward trend in monkeypox cases and a global outbreak. However, reports of severe cases are relatively limited. In this study, we report a case of severe monkeypox in a patient with HIV. The patient presente...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | iLabmed |
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| Online Access: | https://doi.org/10.1002/ila2.32 |
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| author | Chuming Chen Weiming Yao Siran Huang Ling Peng Shiyan Feng Weibo Wu Yunlan Yi Zhiqiang Cheng Yang Yang Yan Yang Liuqing Yang Hongzhou Lu Fuxiang Wang |
| author_facet | Chuming Chen Weiming Yao Siran Huang Ling Peng Shiyan Feng Weibo Wu Yunlan Yi Zhiqiang Cheng Yang Yang Yan Yang Liuqing Yang Hongzhou Lu Fuxiang Wang |
| author_sort | Chuming Chen |
| collection | DOAJ |
| description | Abstract Since the first reported case of monkeypox in the UK in May 2022, there has been an upward trend in monkeypox cases and a global outbreak. However, reports of severe cases are relatively limited. In this study, we report a case of severe monkeypox in a patient with HIV. The patient presented with skin lesions that started on his face and around the penis and persisted for several months. Throughout the course of the disease, he received systematic symptomatic supportive treatment, topical remedies, and special care for the rash. He also underwent cidofovir antiviral therapy and smallpox‐vaccinated healthy population‐derived plasma therapy in succession, with the condition ultimately showing improvement after plasma treatment. After more than 3 months of hospitalization, he fully recovered. To the best of our knowledge, this is the first reported use of smallpox‐vaccinated healthy population‐derived plasma in the treatment of severe monkeypox cases. |
| format | Article |
| id | doaj-art-9b8490e012b34777bb6cbb141629be83 |
| institution | Kabale University |
| issn | 2834-443X 2834-4448 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | iLabmed |
| spelling | doaj-art-9b8490e012b34777bb6cbb141629be832025-08-20T03:40:50ZengWileyiLabmed2834-443X2834-44482024-03-0121606610.1002/ila2.32Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case reportChuming Chen0Weiming Yao1Siran Huang2Ling Peng3Shiyan Feng4Weibo Wu5Yunlan Yi6Zhiqiang Cheng7Yang Yang8Yan Yang9Liuqing Yang10Hongzhou Lu11Fuxiang Wang12Department of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Pathology National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Blood Transfusion National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaDepartment of Infectious Diseases National Clinical Research Center for Infectious Disease Shenzhen Third People's Hospital The Second Affiliated Hospital School of Medicine Southern University of Science and Technology Shenzhen Guangdong ChinaAbstract Since the first reported case of monkeypox in the UK in May 2022, there has been an upward trend in monkeypox cases and a global outbreak. However, reports of severe cases are relatively limited. In this study, we report a case of severe monkeypox in a patient with HIV. The patient presented with skin lesions that started on his face and around the penis and persisted for several months. Throughout the course of the disease, he received systematic symptomatic supportive treatment, topical remedies, and special care for the rash. He also underwent cidofovir antiviral therapy and smallpox‐vaccinated healthy population‐derived plasma therapy in succession, with the condition ultimately showing improvement after plasma treatment. After more than 3 months of hospitalization, he fully recovered. To the best of our knowledge, this is the first reported use of smallpox‐vaccinated healthy population‐derived plasma in the treatment of severe monkeypox cases.https://doi.org/10.1002/ila2.32antiviral therapyco‐infectionHIVmonkeypoxplasma therapysevere infection |
| spellingShingle | Chuming Chen Weiming Yao Siran Huang Ling Peng Shiyan Feng Weibo Wu Yunlan Yi Zhiqiang Cheng Yang Yang Yan Yang Liuqing Yang Hongzhou Lu Fuxiang Wang Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report iLabmed antiviral therapy co‐infection HIV monkeypox plasma therapy severe infection |
| title | Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report |
| title_full | Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report |
| title_fullStr | Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report |
| title_full_unstemmed | Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report |
| title_short | Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpox‐vaccinated healthy population: A case report |
| title_sort | successful treatment of severe monkeypox case with advanced hiv infection using plasma from smallpox vaccinated healthy population a case report |
| topic | antiviral therapy co‐infection HIV monkeypox plasma therapy severe infection |
| url | https://doi.org/10.1002/ila2.32 |
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