Muscle-Restricted Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Knockout Partially Corrects Muscle Contractility After Spinal Cord Injury in Mice

Muscle-Restricted Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Knockout Partially Corrects Muscle Contractility After Spinal Cord Injury in Mice

Spinal cord injury (SCI) results in severe atrophy of skeletal muscle in paralyzed regions, and a decrease in the force generated by muscle per unit of cross-sectional area. Oxidation of skeletal muscle ryanodine 1 receptors (RyR1) reduces contractile force as a result of reduced binding of calstabi...

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Bibliographic Details
Main Authors: Carlos A. Toro, Rita De Gasperi, Abdurrahman Aslan, Nicholas Johnson, Mustafa M. Siddiq, Christine Chow, Wei Zhao, Lauren Harlow, Zachary Graham, Xin-Hua Liu, Junichi Sadoshima, Ravi Iyengar, Christopher P. Cardozo
Format: Article
Language:English
Published: Mary Ann Liebert 2024-11-01
Series:Neurotrauma Reports
Subjects:
muscle cKO
muscle contractility
Nox4
SCI mouse models
transection SCI
Online Access:https://www.liebertpub.com/doi/10.1089/neur.2023.0089
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https://www.liebertpub.com/doi/10.1089/neur.2023.0089

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