Targeting the AURKB-MAD2L2 Axis Disrupts the DNA Damage Response and Glycolysis to Inhibit Colorectal Cancer Progression

Targeting the AURKB-MAD2L2 Axis Disrupts the DNA Damage Response and Glycolysis to Inhibit Colorectal Cancer Progression

Background: Dysregulated metabolic pathways, including glycolysis and a compromised DNA damage response (DDR), are linked to the progression of colorectal cancer (CRC). The mitotic arrest deficient-like 2 (MAD2L2) and aurora kinase B (AURKB) genes play roles in cell cycle regulati...

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Bibliographic Details
Main Authors: Shengjie Li, Jiayou Ye, Kaifeng Yang, Chengfan Xu, Zhixiang Qin, Yiyang Xue, Lanjian Yu, Tianyu Zhou, Ziming Yin, Bin Sun, Jun Xu
Format: Article
Language:English
Published: IMR Press 2025-02-01
Series:Frontiers in Bioscience-Landmark
Subjects:
colorectal cancer
aurkb
mad2l2
dna damage response
glycolysis
Online Access:https://www.imrpress.com/journal/FBL/30/2/10.31083/FBL26532
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