Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance
Abstract Regulatory elements controlling gene expression fine-tune bacterial responses to environmental cues, including antimicrobials, to optimize survival. Acinetobacter baumannii, a pathogen notorious for antimicrobial resistance, relies on efficient efflux systems. Though the role of efflux syst...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-024-00074-z |
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| author | Ruwani L. Wimalasekara Dawn White Ayush Kumar |
| author_facet | Ruwani L. Wimalasekara Dawn White Ayush Kumar |
| author_sort | Ruwani L. Wimalasekara |
| collection | DOAJ |
| description | Abstract Regulatory elements controlling gene expression fine-tune bacterial responses to environmental cues, including antimicrobials, to optimize survival. Acinetobacter baumannii, a pathogen notorious for antimicrobial resistance, relies on efficient efflux systems. Though the role of efflux systems in antibiotic expulsion are well recognized, the regulatory mechanisms controlling their expression remain understudied. This review explores the current understanding of these regulators, aiming to inspire strategies to combat bacterial resistance and improve therapeutic outcomes. |
| format | Article |
| id | doaj-art-9b75cd8d613441adbe40b23162e2622c |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-9b75cd8d613441adbe40b23162e2622c2025-01-26T12:54:17ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-01-01311910.1038/s44259-024-00074-zTargeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistanceRuwani L. Wimalasekara0Dawn White1Ayush Kumar2Department of Microbiology, University of ManitobaDepartment of Microbiology, University of ManitobaDepartment of Microbiology, University of ManitobaAbstract Regulatory elements controlling gene expression fine-tune bacterial responses to environmental cues, including antimicrobials, to optimize survival. Acinetobacter baumannii, a pathogen notorious for antimicrobial resistance, relies on efficient efflux systems. Though the role of efflux systems in antibiotic expulsion are well recognized, the regulatory mechanisms controlling their expression remain understudied. This review explores the current understanding of these regulators, aiming to inspire strategies to combat bacterial resistance and improve therapeutic outcomes.https://doi.org/10.1038/s44259-024-00074-z |
| spellingShingle | Ruwani L. Wimalasekara Dawn White Ayush Kumar Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance npj Antimicrobials and Resistance |
| title | Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance |
| title_full | Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance |
| title_fullStr | Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance |
| title_full_unstemmed | Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance |
| title_short | Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance |
| title_sort | targeting acinetobacter baumannii resistance nodulation division efflux pump transcriptional regulators to combat antimicrobial resistance |
| url | https://doi.org/10.1038/s44259-024-00074-z |
| work_keys_str_mv | AT ruwanilwimalasekara targetingacinetobacterbaumanniiresistancenodulationdivisioneffluxpumptranscriptionalregulatorstocombatantimicrobialresistance AT dawnwhite targetingacinetobacterbaumanniiresistancenodulationdivisioneffluxpumptranscriptionalregulatorstocombatantimicrobialresistance AT ayushkumar targetingacinetobacterbaumanniiresistancenodulationdivisioneffluxpumptranscriptionalregulatorstocombatantimicrobialresistance |