Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice
Results: The study found that Arak and its metabolite, ethanol, have a dose-dependent negative impact on the liver and kidney’s microstructures, and Arak has a significant dose-dependent effect on decreasing body weight, increasing serum levels of aspartate transaminase and alanine aminotransferase,...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/jnme/9304159 |
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| author | Rebuma Sorsa Niguse Hamba Daba Abdissa Zelalem Banjaw Hawi Gobena Muntaha Hamza Melese Abere Tilahun Alemayehu Nigatu |
| author_facet | Rebuma Sorsa Niguse Hamba Daba Abdissa Zelalem Banjaw Hawi Gobena Muntaha Hamza Melese Abere Tilahun Alemayehu Nigatu |
| author_sort | Rebuma Sorsa |
| collection | DOAJ |
| description | Results: The study found that Arak and its metabolite, ethanol, have a dose-dependent negative impact on the liver and kidney’s microstructures, and Arak has a significant dose-dependent effect on decreasing body weight, increasing serum levels of aspartate transaminase and alanine aminotransferase, and elevating serum levels of blood, urea, and nitrogen and creatinine in Swiss albino mice. Higher doses of 1 mL of 40% and 1 mL of 45% Arak/kg caused inflammation, edema, obscured Bowman’s capsule, foamy appearance, and necrosis, while lower doses of 1 mL of 20% Arak/kg had a lesser impact. Further research is needed to evaluate the effect of Arak on human hepatorenal structures and biomarkers. |
| format | Article |
| id | doaj-art-9b711fabc8ad4514acbcb9aca014ed9e |
| institution | Kabale University |
| issn | 2090-0732 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-9b711fabc8ad4514acbcb9aca014ed9e2025-08-20T03:29:26ZengWileyJournal of Nutrition and Metabolism2090-07322025-01-01202510.1155/jnme/9304159Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino MiceRebuma Sorsa0Niguse Hamba1Daba Abdissa2Zelalem Banjaw3Hawi Gobena4Muntaha Hamza5Melese Abere6Tilahun Alemayehu Nigatu7Department of Biomedical SciencesDepartment of Biomedical SciencesDepartment of Biomedical SciencesDepartment of Biomedical SciencesDepartment of NursingDepartment of BiologyDepartment of PathologyDepartment of Biomedical SciencesResults: The study found that Arak and its metabolite, ethanol, have a dose-dependent negative impact on the liver and kidney’s microstructures, and Arak has a significant dose-dependent effect on decreasing body weight, increasing serum levels of aspartate transaminase and alanine aminotransferase, and elevating serum levels of blood, urea, and nitrogen and creatinine in Swiss albino mice. Higher doses of 1 mL of 40% and 1 mL of 45% Arak/kg caused inflammation, edema, obscured Bowman’s capsule, foamy appearance, and necrosis, while lower doses of 1 mL of 20% Arak/kg had a lesser impact. Further research is needed to evaluate the effect of Arak on human hepatorenal structures and biomarkers.http://dx.doi.org/10.1155/jnme/9304159 |
| spellingShingle | Rebuma Sorsa Niguse Hamba Daba Abdissa Zelalem Banjaw Hawi Gobena Muntaha Hamza Melese Abere Tilahun Alemayehu Nigatu Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice Journal of Nutrition and Metabolism |
| title | Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice |
| title_full | Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice |
| title_fullStr | Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice |
| title_full_unstemmed | Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice |
| title_short | Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice |
| title_sort | experimental evaluation of dose dependent hepatorenal toxicity of traditionally prepared arak in swiss albino mice |
| url | http://dx.doi.org/10.1155/jnme/9304159 |
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