Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway

Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway

Abstract Insulin-like growth factor-binding protein 5 (IGFBP5) is associated with nonalcoholic fatty liver disease (NAFLD). IGFBP5 has a higher binding affinity to IGF1 and modulates its effects in serum. However, the effect of exercise on its expression remains unclear. Hence, this study investigat...

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Bibliographic Details
Main Authors: Yang Yu, Guanxiong Zhu, Zeyu Zhang, Huiguo Wang, Liting Zeng, Jingbo Xia, Xiaoguang Liu, Chunlu Fang, Shujing Liu, Yunjie Yang, Lina Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Exercise
NAFLD
IGFBP5/IGF1 ratio
IRS1
Akt
AMPK
Online Access:https://doi.org/10.1038/s41598-025-07857-y
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