Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregul...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/3057624 |
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| _version_ | 1832552581563416576 |
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| author | Mengyuan Wang Quan Yuan Liang Xie |
| author_facet | Mengyuan Wang Quan Yuan Liang Xie |
| author_sort | Mengyuan Wang |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation. |
| format | Article |
| id | doaj-art-9b68a6702a7d4aa5b2698ed5d7afb4a3 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9b68a6702a7d4aa5b2698ed5d7afb4a32025-02-03T05:58:24ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/30576243057624Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical ApplicationMengyuan Wang0Quan Yuan1Liang Xie2State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaMesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation.http://dx.doi.org/10.1155/2018/3057624 |
| spellingShingle | Mengyuan Wang Quan Yuan Liang Xie Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application Stem Cells International |
| title | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
| title_full | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
| title_fullStr | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
| title_full_unstemmed | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
| title_short | Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application |
| title_sort | mesenchymal stem cell based immunomodulation properties and clinical application |
| url | http://dx.doi.org/10.1155/2018/3057624 |
| work_keys_str_mv | AT mengyuanwang mesenchymalstemcellbasedimmunomodulationpropertiesandclinicalapplication AT quanyuan mesenchymalstemcellbasedimmunomodulationpropertiesandclinicalapplication AT liangxie mesenchymalstemcellbasedimmunomodulationpropertiesandclinicalapplication |