Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis

Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis

Abstract Inflammatory bowel disease (IBD) presents a significant clinical challenge, yet the way bioactive gases are implicated remains elusive. We detect elevated colonic Nos2 levels in both IBD patients and mice undergoing diverse colitis. Additionally, Nos2 deficiency significantly aggravates ant...

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Main Authors: Xingyu Zhao, Jun Li, Yime Zhang, Luni Hu, Di Wu, Jiayu Wu, Ruiqing Lyu, Peng Li, Gao An, Rongli Cui, Tao Sun, Pingping Zhu, Lin Bai, Changtao Jiang, Chao Zhong
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60969-x
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