Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective
Periodontitis is the sixth-most prevalent chronic inflammatory disease and gradually devastates tooth-supporting tissue. The complexity of periodontal tissue and the local inflammatory microenvironment poses great challenges to tissue repair. Recently, stem cells have been considered a promising str...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/9836518 |
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| _version_ | 1849404466655133696 |
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| author | Mengyuan Wang Jiang Xie Cong Wang Dingping Zhong Liang Xie Hongzhi Fang |
| author_facet | Mengyuan Wang Jiang Xie Cong Wang Dingping Zhong Liang Xie Hongzhi Fang |
| author_sort | Mengyuan Wang |
| collection | DOAJ |
| description | Periodontitis is the sixth-most prevalent chronic inflammatory disease and gradually devastates tooth-supporting tissue. The complexity of periodontal tissue and the local inflammatory microenvironment poses great challenges to tissue repair. Recently, stem cells have been considered a promising strategy to treat tissue damage and inflammation because of their remarkable properties, including stemness, proliferation, migration, multilineage differentiation, and immunomodulation. Several varieties of stem cells can potentially be applied to periodontal regeneration, including dental mesenchymal stem cells (DMSCs), nonodontogenic stem cells, and induced pluripotent stem cells (iPSCs). In particular, these stem cells possess extensive immunoregulatory capacities. In periodontitis, these cells can exert anti-inflammatory effects and regenerate the periodontium. Stem cells derived from infected tissue possess typical stem cell characteristics with lower immunogenicity and immunosuppression. Several studies have demonstrated that these cells can also regenerate the periodontium. Furthermore, the interaction of stem cells with the surrounding infected microenvironment is critical to periodontal tissue repair. Though the immunomodulatory capabilities of stem cells are not entirely clarified, they show promise for therapeutic application in periodontitis. Here, we summarize the potential of stem cells for periodontium regeneration in periodontitis and focus on their characteristics and immunomodulatory properties as well as challenges and perspectives. |
| format | Article |
| id | doaj-art-9b635c5904ad469da9ec5d2cb4532f25 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9b635c5904ad469da9ec5d2cb4532f252025-08-20T03:36:58ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/98365189836518Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future ProspectiveMengyuan Wang0Jiang Xie1Cong Wang2Dingping Zhong3Liang Xie4Hongzhi Fang5Department of Stomatology, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610000, ChinaThe Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610000, ChinaDepartment of Stomatology, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610000, ChinaThe Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610000, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, ChinaDepartment of Stomatology, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610000, ChinaPeriodontitis is the sixth-most prevalent chronic inflammatory disease and gradually devastates tooth-supporting tissue. The complexity of periodontal tissue and the local inflammatory microenvironment poses great challenges to tissue repair. Recently, stem cells have been considered a promising strategy to treat tissue damage and inflammation because of their remarkable properties, including stemness, proliferation, migration, multilineage differentiation, and immunomodulation. Several varieties of stem cells can potentially be applied to periodontal regeneration, including dental mesenchymal stem cells (DMSCs), nonodontogenic stem cells, and induced pluripotent stem cells (iPSCs). In particular, these stem cells possess extensive immunoregulatory capacities. In periodontitis, these cells can exert anti-inflammatory effects and regenerate the periodontium. Stem cells derived from infected tissue possess typical stem cell characteristics with lower immunogenicity and immunosuppression. Several studies have demonstrated that these cells can also regenerate the periodontium. Furthermore, the interaction of stem cells with the surrounding infected microenvironment is critical to periodontal tissue repair. Though the immunomodulatory capabilities of stem cells are not entirely clarified, they show promise for therapeutic application in periodontitis. Here, we summarize the potential of stem cells for periodontium regeneration in periodontitis and focus on their characteristics and immunomodulatory properties as well as challenges and perspectives.http://dx.doi.org/10.1155/2020/9836518 |
| spellingShingle | Mengyuan Wang Jiang Xie Cong Wang Dingping Zhong Liang Xie Hongzhi Fang Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective Stem Cells International |
| title | Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective |
| title_full | Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective |
| title_fullStr | Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective |
| title_full_unstemmed | Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective |
| title_short | Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective |
| title_sort | immunomodulatory properties of stem cells in periodontitis current status and future prospective |
| url | http://dx.doi.org/10.1155/2020/9836518 |
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