Recent Trends in Tailored Treatments for Helicobacter pylori Infection
The efficacy of the standard triple eradication regimen for Helicobacter pylori (H. pylori) infection is gradually decreasing due to increased antibiotic resistance of H. pylori, which is represented by clarithromycin resistance. This is an important issue for clinicians. Tailored therapies for H. p...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean College of Helicobacter and Upper Gastrointestinal Research
2021-06-01
|
| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2021-0005.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849694145226997760 |
|---|---|
| author | Hyungchul Park Jeong Hoon Lee |
| author_facet | Hyungchul Park Jeong Hoon Lee |
| author_sort | Hyungchul Park |
| collection | DOAJ |
| description | The efficacy of the standard triple eradication regimen for Helicobacter pylori (H. pylori) infection is gradually decreasing due to increased antibiotic resistance of H. pylori, which is represented by clarithromycin resistance. This is an important issue for clinicians. Tailored therapies for H. pylori infection, including culture-based susceptibility testing and molecular methods detecting genetic mutations that increase resistance to antibiotics, have been introduced to overcome the high treatment failure rate of the standard triple regimen. The treatment results have been satisfactory. In addition to the H. pylori-related factors, the CYP2C19 gene polymorphism, in terms of host factors, affects the effectiveness of proton pump inhibitors. This article reviews the status of the tailored therapies for H. pylori infection along with the proven therapeutic effects and benefits of such treatments in Korea, where the resistance to antibiotics such as clarithromycin, metronidazole, and quinolone is prevalent. |
| format | Article |
| id | doaj-art-9b5e69328cf84128bcb7bc287eeee216 |
| institution | DOAJ |
| issn | 1738-3331 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-9b5e69328cf84128bcb7bc287eeee2162025-08-20T03:20:12ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312021-06-0121211512110.7704/kjhugr.2021.0005676Recent Trends in Tailored Treatments for Helicobacter pylori InfectionHyungchul Park0Jeong Hoon Lee1Department of Gastroenterology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, KoreaDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaThe efficacy of the standard triple eradication regimen for Helicobacter pylori (H. pylori) infection is gradually decreasing due to increased antibiotic resistance of H. pylori, which is represented by clarithromycin resistance. This is an important issue for clinicians. Tailored therapies for H. pylori infection, including culture-based susceptibility testing and molecular methods detecting genetic mutations that increase resistance to antibiotics, have been introduced to overcome the high treatment failure rate of the standard triple regimen. The treatment results have been satisfactory. In addition to the H. pylori-related factors, the CYP2C19 gene polymorphism, in terms of host factors, affects the effectiveness of proton pump inhibitors. This article reviews the status of the tailored therapies for H. pylori infection along with the proven therapeutic effects and benefits of such treatments in Korea, where the resistance to antibiotics such as clarithromycin, metronidazole, and quinolone is prevalent.http://www.helicojournal.org/upload/pdf/kjhugr-2021-0005.pdfdrug resistancetherapytherapeutics |
| spellingShingle | Hyungchul Park Jeong Hoon Lee Recent Trends in Tailored Treatments for Helicobacter pylori Infection The Korean Journal of Helicobacter and Upper Gastrointestinal Research drug resistance therapy therapeutics |
| title | Recent Trends in Tailored Treatments for Helicobacter pylori Infection |
| title_full | Recent Trends in Tailored Treatments for Helicobacter pylori Infection |
| title_fullStr | Recent Trends in Tailored Treatments for Helicobacter pylori Infection |
| title_full_unstemmed | Recent Trends in Tailored Treatments for Helicobacter pylori Infection |
| title_short | Recent Trends in Tailored Treatments for Helicobacter pylori Infection |
| title_sort | recent trends in tailored treatments for helicobacter pylori infection |
| topic | drug resistance therapy therapeutics |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2021-0005.pdf |
| work_keys_str_mv | AT hyungchulpark recenttrendsintailoredtreatmentsforhelicobacterpyloriinfection AT jeonghoonlee recenttrendsintailoredtreatmentsforhelicobacterpyloriinfection |