Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study
Abstract Background There is scarce literature evaluating long term psychological or Quality of Life (QoL) outcomes in family members of ICU survivors, who have not experienced invasive ventilation. The objective was to compare long-term psychological symptoms and QoL outcomes in family members of i...
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SpringerOpen
2025-01-01
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| Series: | Annals of Intensive Care |
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| Online Access: | https://doi.org/10.1186/s13613-025-01420-8 |
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| author | Sumeet Rai Dale M. Needham Rhonda Brown Teresa Neeman Krishnaswamy Sundararajan Arvind Rajamani Rakshit Panwar Mary Nourse Frank M. P. van Haren Imogen Mitchell for the PRICE study investigators |
| author_facet | Sumeet Rai Dale M. Needham Rhonda Brown Teresa Neeman Krishnaswamy Sundararajan Arvind Rajamani Rakshit Panwar Mary Nourse Frank M. P. van Haren Imogen Mitchell for the PRICE study investigators |
| author_sort | Sumeet Rai |
| collection | DOAJ |
| description | Abstract Background There is scarce literature evaluating long term psychological or Quality of Life (QoL) outcomes in family members of ICU survivors, who have not experienced invasive ventilation. The objective was to compare long-term psychological symptoms and QoL outcomes in family members of intubated versus non-intubated ICU survivors and to evaluate dyadic relationships between paired family members and survivors. Methods Prospective, multicentre cohort study among four medical-surgical ICUs in Australia. Adult family members of ICU survivors and family-survivor dyads had follow-up assessments (3 and 12 months after ICU discharge), using Impact of Event Scale-Revised; Depression, Anxiety Stress Scales-21; EQ-5D-5L. Dyadic relationships examined associations of psychological symptoms or QoL impairments. Results Of 144 family members (75% female, 54% partners/spouses) recruited, 59% cared for previously intubated survivors. Overall, 83% (110/132) of eligible family members completed ≥ 1 follow-up. In family members of intubated vs non-intubated survivors, clinically significant psychological symptoms (PTSD/depression/anxiety) were reported by 48% vs 33% at 3-months (p = 0.15); and 39% vs 25% at 12-months (p = 0.23). Family self-rated their QoL with a mean score of 83 (SD 13) on a visual analogue scale (range 0–100), and > 30% reported problems in pain/discomfort or anxiety/depression domains at 12-months. Family members were more likely to have persistent psychological symptoms of PTSD [OR 4.9, 95% CI (1.47–16.1), p = 0.01] or depression [OR 14.6, 95% CI (2.9–72.6), p = 0.001]; or QoL domain problems with pain/discomfort [OR 6.5, 95% CI (1.14–36.8), p = 0.03] or anxiety/depression [OR 3.5, 95% CI (1.02–12.1), p = 0.04], when the paired survivor also reported the same symptoms. Conclusions Almost one-third of the family members of ICU survivors reported persistent psychological symptoms and QoL problems at 12-months. There was a noticeable dyad effect with family members more likely to have persistent symptoms of PTSD, depression, and problems in QoL domains when the paired ICU survivors experienced similar symptoms. The family members of non-intubated ICU survivors had an equal propensity to develop long-term psychological distress and should be included in long-term outcome studies. Future recovery intervention trials should be aimed at ICU family-survivor dyads. Trial registration ACTRN12615000880549 |
| format | Article |
| id | doaj-art-9b5daf7895894f168f32088fb54b1f4d |
| institution | Kabale University |
| issn | 2110-5820 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | Annals of Intensive Care |
| spelling | doaj-art-9b5daf7895894f168f32088fb54b1f4d2025-01-26T12:52:22ZengSpringerOpenAnnals of Intensive Care2110-58202025-01-0115111010.1186/s13613-025-01420-8Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort studySumeet Rai0Dale M. Needham1Rhonda Brown2Teresa Neeman3Krishnaswamy Sundararajan4Arvind Rajamani5Rakshit Panwar6Mary Nourse7Frank M. P. van Haren8Imogen Mitchell9for the PRICE study investigatorsSchool of Medicine and Psychology, Australian National UniversityJohn Hopkins University School of Medicine and School of NursingResearch School of Psychology, Australian National UniversityBiological Data Science Institute, College of Science, Australian National UniversityIntensive Care Unit, Royal Adelaide HospitalIntensive Care Unit, Nepean Hospital, KingswoodIntensive Care Unit, John Hunter HospitalIntensive Care Unit, Canberra Hospital, Canberra Health ServicesSchool of Medicine and Psychology, Australian National UniversitySchool of Medicine and Psychology, Australian National UniversityAbstract Background There is scarce literature evaluating long term psychological or Quality of Life (QoL) outcomes in family members of ICU survivors, who have not experienced invasive ventilation. The objective was to compare long-term psychological symptoms and QoL outcomes in family members of intubated versus non-intubated ICU survivors and to evaluate dyadic relationships between paired family members and survivors. Methods Prospective, multicentre cohort study among four medical-surgical ICUs in Australia. Adult family members of ICU survivors and family-survivor dyads had follow-up assessments (3 and 12 months after ICU discharge), using Impact of Event Scale-Revised; Depression, Anxiety Stress Scales-21; EQ-5D-5L. Dyadic relationships examined associations of psychological symptoms or QoL impairments. Results Of 144 family members (75% female, 54% partners/spouses) recruited, 59% cared for previously intubated survivors. Overall, 83% (110/132) of eligible family members completed ≥ 1 follow-up. In family members of intubated vs non-intubated survivors, clinically significant psychological symptoms (PTSD/depression/anxiety) were reported by 48% vs 33% at 3-months (p = 0.15); and 39% vs 25% at 12-months (p = 0.23). Family self-rated their QoL with a mean score of 83 (SD 13) on a visual analogue scale (range 0–100), and > 30% reported problems in pain/discomfort or anxiety/depression domains at 12-months. Family members were more likely to have persistent psychological symptoms of PTSD [OR 4.9, 95% CI (1.47–16.1), p = 0.01] or depression [OR 14.6, 95% CI (2.9–72.6), p = 0.001]; or QoL domain problems with pain/discomfort [OR 6.5, 95% CI (1.14–36.8), p = 0.03] or anxiety/depression [OR 3.5, 95% CI (1.02–12.1), p = 0.04], when the paired survivor also reported the same symptoms. Conclusions Almost one-third of the family members of ICU survivors reported persistent psychological symptoms and QoL problems at 12-months. There was a noticeable dyad effect with family members more likely to have persistent symptoms of PTSD, depression, and problems in QoL domains when the paired ICU survivors experienced similar symptoms. The family members of non-intubated ICU survivors had an equal propensity to develop long-term psychological distress and should be included in long-term outcome studies. Future recovery intervention trials should be aimed at ICU family-survivor dyads. Trial registration ACTRN12615000880549https://doi.org/10.1186/s13613-025-01420-8Post-intensive care syndrome-familyIntensive carePsychologyQuality of lifeDyads |
| spellingShingle | Sumeet Rai Dale M. Needham Rhonda Brown Teresa Neeman Krishnaswamy Sundararajan Arvind Rajamani Rakshit Panwar Mary Nourse Frank M. P. van Haren Imogen Mitchell for the PRICE study investigators Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study Annals of Intensive Care Post-intensive care syndrome-family Intensive care Psychology Quality of life Dyads |
| title | Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study |
| title_full | Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study |
| title_fullStr | Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study |
| title_full_unstemmed | Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study |
| title_short | Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study |
| title_sort | psychological symptoms quality of life and dyadic relations in family members of intensive care survivors a multicentre prospective longitudinal cohort study |
| topic | Post-intensive care syndrome-family Intensive care Psychology Quality of life Dyads |
| url | https://doi.org/10.1186/s13613-025-01420-8 |
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