Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography
Aim. To perform quantitative evaluation of the degree of white matter tract abnormalities in children with spastic cerebral palsy by magnetic resonance tractography to determine severity of the disease, as well as to carry out a dynamic assessment of treatment effectiveness.Materials and methods. Th...
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Siberian State Medical University (Tomsk)
2021-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4480 |
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| author | E. A. Klyuev G. E. Sheiko M. G. Dunaev E. V. Lobanova M. V. Rasteryaeva E. D. Sharabrin |
| author_facet | E. A. Klyuev G. E. Sheiko M. G. Dunaev E. V. Lobanova M. V. Rasteryaeva E. D. Sharabrin |
| author_sort | E. A. Klyuev |
| collection | DOAJ |
| description | Aim. To perform quantitative evaluation of the degree of white matter tract abnormalities in children with spastic cerebral palsy by magnetic resonance tractography to determine severity of the disease, as well as to carry out a dynamic assessment of treatment effectiveness.Materials and methods. The study included 46 children (32 males, 14 females; average age 5.4 ± 1.1 years). The participants were divided into two groups. The experimental group consisted of 23 children with spastic cerebral palsy. The control group included 23 children without any neurological disorder. Examination of the brain was performed on the Siemens Essenza 1,5 Т system (Siemens, Germany) and included magnetic resonance tractography to reconstruct the major white matter tracts. The number of fibers, average fractional anisotropy value, apparent diffusion coefficient, and coefficient of myelination of major white matter tracts in the brain were calculated and analyzed.Results. We found a significant difference in the above-stated parameters between the groups. The experimental group showed a decrease in the absolute number of fibers at the central and posterior segments of the corpus callosum, corticospinal tracts, and left inferior longitudinal fasciculus. Besides, we detected a decrease in fractional anisotropy at 2–5 segments of the corpus callosum and right lateral corticospinal tract, an increase in the apparent diffusion coefficient at 2, 4, and 5 segments of the corpus callosum and left lateral corticospinal tract, and a decrease in the myelination coefficient in all the examined tracts, except for superior longitudinal fasciculus. We revealed a positive correlation between the intensity of the motor disturbance and the coefficient of myelination at the anterior corpus callosum and inferior longitudinal fasciculus.Conclusion. Magnetic resonance tractography is an informative technique for unbiased evaluation of white matter tract anatomy, as well the level and degree of motor tract damage. The most useful characteristics of white matter tract anatomy are the absolute number of fibers in the tract, fractional anisotropy, and coefficient of myelination. Some of them correlated with the intensity of motor disturbance, so they can be regarded as potential predictors of rehabilitation potential. |
| format | Article |
| id | doaj-art-9b5d27b6313e4ae7890ed2fb45832a43 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-9b5d27b6313e4ae7890ed2fb45832a432025-08-20T03:38:06ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842021-10-01203546110.20538/1682-0363-2021-3-54-612812Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractographyE. A. Klyuev0G. E. Sheiko1M. G. Dunaev2E. V. Lobanova3M. V. Rasteryaeva4E. D. Sharabrin5Privolzhsky Research Medical UniversityPrivolzhsky Research Medical University“Medical and Diagnostic Center of the Dr. Berezin Medical Institute – Nizhny Novgorod” LLC (“MDC MIBS-NN” LLC)Privolzhsky Research Medical UniversityPrivolzhsky Research Medical UniversityPrivolzhsky Research Medical UniversityAim. To perform quantitative evaluation of the degree of white matter tract abnormalities in children with spastic cerebral palsy by magnetic resonance tractography to determine severity of the disease, as well as to carry out a dynamic assessment of treatment effectiveness.Materials and methods. The study included 46 children (32 males, 14 females; average age 5.4 ± 1.1 years). The participants were divided into two groups. The experimental group consisted of 23 children with spastic cerebral palsy. The control group included 23 children without any neurological disorder. Examination of the brain was performed on the Siemens Essenza 1,5 Т system (Siemens, Germany) and included magnetic resonance tractography to reconstruct the major white matter tracts. The number of fibers, average fractional anisotropy value, apparent diffusion coefficient, and coefficient of myelination of major white matter tracts in the brain were calculated and analyzed.Results. We found a significant difference in the above-stated parameters between the groups. The experimental group showed a decrease in the absolute number of fibers at the central and posterior segments of the corpus callosum, corticospinal tracts, and left inferior longitudinal fasciculus. Besides, we detected a decrease in fractional anisotropy at 2–5 segments of the corpus callosum and right lateral corticospinal tract, an increase in the apparent diffusion coefficient at 2, 4, and 5 segments of the corpus callosum and left lateral corticospinal tract, and a decrease in the myelination coefficient in all the examined tracts, except for superior longitudinal fasciculus. We revealed a positive correlation between the intensity of the motor disturbance and the coefficient of myelination at the anterior corpus callosum and inferior longitudinal fasciculus.Conclusion. Magnetic resonance tractography is an informative technique for unbiased evaluation of white matter tract anatomy, as well the level and degree of motor tract damage. The most useful characteristics of white matter tract anatomy are the absolute number of fibers in the tract, fractional anisotropy, and coefficient of myelination. Some of them correlated with the intensity of motor disturbance, so they can be regarded as potential predictors of rehabilitation potential.https://bulletin.ssmu.ru/jour/article/view/4480cerebral palsydiffusion tensor imagingtractographyfractional anisotropycoefficient of myelinationneuroimagingmotor disturbance |
| spellingShingle | E. A. Klyuev G. E. Sheiko M. G. Dunaev E. V. Lobanova M. V. Rasteryaeva E. D. Sharabrin Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography Бюллетень сибирской медицины cerebral palsy diffusion tensor imaging tractography fractional anisotropy coefficient of myelination neuroimaging motor disturbance |
| title | Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography |
| title_full | Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography |
| title_fullStr | Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography |
| title_full_unstemmed | Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography |
| title_short | Neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography |
| title_sort | neurovisualization features of brain anatomy in children with spastic cerebral palsy revealed by magnetic resonance tractography |
| topic | cerebral palsy diffusion tensor imaging tractography fractional anisotropy coefficient of myelination neuroimaging motor disturbance |
| url | https://bulletin.ssmu.ru/jour/article/view/4480 |
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