Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis
Background Some adipose-related parameters exhibit distinct prognostic value in patients with cirrhosis. However, the magnitude and direction of the association between individual adipose parameter and mortality in patients with cirrhosis are unclear.Aim This study aimed to evaluate the association...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2473627 |
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| author | Zhang Wen Shuyue Tuo Qiuju Ran Jia Yuan Yong Li Ying Zhang Danyan Chang Chan Li Shejiao Dai Jinhai Wang Xinxing Tantai |
| author_facet | Zhang Wen Shuyue Tuo Qiuju Ran Jia Yuan Yong Li Ying Zhang Danyan Chang Chan Li Shejiao Dai Jinhai Wang Xinxing Tantai |
| author_sort | Zhang Wen |
| collection | DOAJ |
| description | Background Some adipose-related parameters exhibit distinct prognostic value in patients with cirrhosis. However, the magnitude and direction of the association between individual adipose parameter and mortality in patients with cirrhosis are unclear.Aim This study aimed to evaluate the association between individual adipose parameter and mortality in patients with cirrhosis using the meta-analysis method.Methods The PubMed, Embase, Web of Science, China Biological Medicine, WanFang, and China National Knowledge Infrastructure databases were searched from inception through December 15, 2023, to identify eligible studies. The impact of each adipose parameter on mortality was assessed by the pooled unadjusted or adjusted hazard ratio (HR) with 95% confidence intervals (CIs) using the random effects model.Results A total of 33 studies involving 9626 patients were included in our analysis, with 11 adipose parameters evaluated. The pooled prevalence of sarcopenic obesity (SO) and myosteatosis in patients with cirrhosis was 15.5% and 34.4%, respectively. In adjusted analysis, each unit increase in subcutaneous adipose tissue index (SATI) (HR: 0.99, 95% CI: 0.98–1.00) or muscle attenuation (MA) (HR: 0.94, 95% CI: 0.90–0.98) and each unit decrease in visceral-to-subcutaneous adipose tissue ratio (VSR) (HR: 1.92, 95% CI: 1.45–2.54) showed an independent association with a decreased risk of mortality. However, concurrent myosteatosis (HR: 1.88, 95% CI: 1.48–2.40) or SO (HR: 2.77, 95% CI: 1.95–3.93) significantly increased the risk of mortality in patients with cirrhosis.Conclusion Decreased SATI or MA, increased VSR, and concurrent myosteatosis or SO were independently associated with a higher risk of mortality in patients with cirrhosis. |
| format | Article |
| id | doaj-art-9b5abe71cf1b4fd98e8eb806fa210032 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-9b5abe71cf1b4fd98e8eb806fa2100322025-08-20T02:38:23ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2473627Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysisZhang Wen0Shuyue Tuo1Qiuju Ran2Jia Yuan3Yong Li4Ying Zhang5Danyan Chang6Chan Li7Shejiao Dai8Jinhai Wang9Xinxing Tantai10Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaBackground Some adipose-related parameters exhibit distinct prognostic value in patients with cirrhosis. However, the magnitude and direction of the association between individual adipose parameter and mortality in patients with cirrhosis are unclear.Aim This study aimed to evaluate the association between individual adipose parameter and mortality in patients with cirrhosis using the meta-analysis method.Methods The PubMed, Embase, Web of Science, China Biological Medicine, WanFang, and China National Knowledge Infrastructure databases were searched from inception through December 15, 2023, to identify eligible studies. The impact of each adipose parameter on mortality was assessed by the pooled unadjusted or adjusted hazard ratio (HR) with 95% confidence intervals (CIs) using the random effects model.Results A total of 33 studies involving 9626 patients were included in our analysis, with 11 adipose parameters evaluated. The pooled prevalence of sarcopenic obesity (SO) and myosteatosis in patients with cirrhosis was 15.5% and 34.4%, respectively. In adjusted analysis, each unit increase in subcutaneous adipose tissue index (SATI) (HR: 0.99, 95% CI: 0.98–1.00) or muscle attenuation (MA) (HR: 0.94, 95% CI: 0.90–0.98) and each unit decrease in visceral-to-subcutaneous adipose tissue ratio (VSR) (HR: 1.92, 95% CI: 1.45–2.54) showed an independent association with a decreased risk of mortality. However, concurrent myosteatosis (HR: 1.88, 95% CI: 1.48–2.40) or SO (HR: 2.77, 95% CI: 1.95–3.93) significantly increased the risk of mortality in patients with cirrhosis.Conclusion Decreased SATI or MA, increased VSR, and concurrent myosteatosis or SO were independently associated with a higher risk of mortality in patients with cirrhosis.https://www.tandfonline.com/doi/10.1080/07853890.2025.2473627Liver cirrhosisadipose tissuebody compositionsurvivalmeta-analysis |
| spellingShingle | Zhang Wen Shuyue Tuo Qiuju Ran Jia Yuan Yong Li Ying Zhang Danyan Chang Chan Li Shejiao Dai Jinhai Wang Xinxing Tantai Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis Annals of Medicine Liver cirrhosis adipose tissue body composition survival meta-analysis |
| title | Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis |
| title_full | Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis |
| title_fullStr | Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis |
| title_full_unstemmed | Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis |
| title_short | Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis |
| title_sort | effect of adipose related parameters on mortality in patients with liver cirrhosis a meta analysis |
| topic | Liver cirrhosis adipose tissue body composition survival meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2473627 |
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