Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use
In today’s pharmaceutical landscape, there’s an urgent need to develop new drug delivery systems that are appealing and effective in ensuring therapeutic adherence, particularly among paediatric patients. The advent of 3D printing in medicine is revolutionizing this space by enabling the creation of...
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| Format: | Article |
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MDPI AG
2024-09-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/10/620 |
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| author | Karla J. Santamaría Brayan J. Anaya Aikaterini Lalatsa Patricia González-Barranco Lucía Cantú-Cárdenas Dolores R. Serrano |
| author_facet | Karla J. Santamaría Brayan J. Anaya Aikaterini Lalatsa Patricia González-Barranco Lucía Cantú-Cárdenas Dolores R. Serrano |
| author_sort | Karla J. Santamaría |
| collection | DOAJ |
| description | In today’s pharmaceutical landscape, there’s an urgent need to develop new drug delivery systems that are appealing and effective in ensuring therapeutic adherence, particularly among paediatric patients. The advent of 3D printing in medicine is revolutionizing this space by enabling the creation of precise, customizable, and visually appealing dosage forms. In this study, we produced 250 mg metformin paediatric gummies based on the semi-solid extrusion (SSE) 3D printing technique. A pharmaceutical ink containing metformin was successfully formulated with optimal flow properties suitable for room-temperature printing. Using a quality by design approach, 3D printing and casting methodologies were compared. The 3D-printed gummies exhibited better firmness and sustained release at earlier times to avoid metformin release in the oral cavity and ensure palatability. The texture and physical appearance match those of gummies commercially available. In conclusion, SSE allowed for the successful manufacture of 3D-printed sugar-free gummies for the treatment of diabetes mellitus for paediatric patients and is an easily translatable approach to clinical practice. |
| format | Article |
| id | doaj-art-9b4fc2979eb04837a6d5d3a416e5c670 |
| institution | OA Journals |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-9b4fc2979eb04837a6d5d3a416e5c6702025-08-20T02:11:05ZengMDPI AGGels2310-28612024-09-01101062010.3390/gels10100620Engineering 3D Printed Gummies Loaded with Metformin for Paediatric UseKarla J. Santamaría0Brayan J. Anaya1Aikaterini Lalatsa2Patricia González-Barranco3Lucía Cantú-Cárdenas4Dolores R. Serrano5Pharmaceutics and Food Technology Department, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, SpainPharmaceutics and Food Technology Department, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, SpainInstitute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UKSchool of Chemistry, Autonomous University of Nuevo León Monterrey, Monterrey 66455, MexicoSchool of Chemistry, Autonomous University of Nuevo León Monterrey, Monterrey 66455, MexicoPharmaceutics and Food Technology Department, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, SpainIn today’s pharmaceutical landscape, there’s an urgent need to develop new drug delivery systems that are appealing and effective in ensuring therapeutic adherence, particularly among paediatric patients. The advent of 3D printing in medicine is revolutionizing this space by enabling the creation of precise, customizable, and visually appealing dosage forms. In this study, we produced 250 mg metformin paediatric gummies based on the semi-solid extrusion (SSE) 3D printing technique. A pharmaceutical ink containing metformin was successfully formulated with optimal flow properties suitable for room-temperature printing. Using a quality by design approach, 3D printing and casting methodologies were compared. The 3D-printed gummies exhibited better firmness and sustained release at earlier times to avoid metformin release in the oral cavity and ensure palatability. The texture and physical appearance match those of gummies commercially available. In conclusion, SSE allowed for the successful manufacture of 3D-printed sugar-free gummies for the treatment of diabetes mellitus for paediatric patients and is an easily translatable approach to clinical practice.https://www.mdpi.com/2310-2861/10/10/6203D printingsemi-solid extrusion (SSE)3D printed gummiesmetforminpaediatrics |
| spellingShingle | Karla J. Santamaría Brayan J. Anaya Aikaterini Lalatsa Patricia González-Barranco Lucía Cantú-Cárdenas Dolores R. Serrano Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use Gels 3D printing semi-solid extrusion (SSE) 3D printed gummies metformin paediatrics |
| title | Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use |
| title_full | Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use |
| title_fullStr | Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use |
| title_full_unstemmed | Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use |
| title_short | Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use |
| title_sort | engineering 3d printed gummies loaded with metformin for paediatric use |
| topic | 3D printing semi-solid extrusion (SSE) 3D printed gummies metformin paediatrics |
| url | https://www.mdpi.com/2310-2861/10/10/620 |
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