Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model
Background. To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis. Methods. Fifteen rabbits were randomly divided into five groups. Group A (n=3) is the control group. The right eyes of animals in Groups B,C, D, and E (n=3, resp...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/171690 |
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| author | Mengmeng Wang |
| author_facet | Mengmeng Wang |
| author_sort | Mengmeng Wang |
| collection | DOAJ |
| description | Background. To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis. Methods. Fifteen rabbits were randomly divided into five groups. Group A (n=3) is the control group. The right eyes of animals in Groups B,C, D, and E (n=3, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C and D were instilled with hyperosmolar drops and glyceraldehyde drops, respectively; the right eyes in Group E were instilled with both hyperosmolar drops and glyceraldehyde drops. Central corneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group. Results. Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, and E at 7 d postoperatively (P<0.05) and in Groups C, D, and E at 14 d postoperatively (P<0.05). Conclusion. Chemical CXL technique using glyceraldehyde improved the CCT and corneal transparency of the rabbit bullous keratopathy models. Topical instillation with glyceraldehyde and hyperosmolar solutions seems to be a good choice for the bullous keratopathy treatment. |
| format | Article |
| id | doaj-art-9b4f243da6bf465a83d7df2c1beff60d |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-9b4f243da6bf465a83d7df2c1beff60d2025-08-20T02:20:26ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/171690171690Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy ModelMengmeng Wang0Hebei Provincial Eye Hospital, Hebei Provincial Ophthalmology Key Lab, Hebei Provincial Institute of Ophthalmology, Xingtai, Hebei 054001, ChinaBackground. To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis. Methods. Fifteen rabbits were randomly divided into five groups. Group A (n=3) is the control group. The right eyes of animals in Groups B,C, D, and E (n=3, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C and D were instilled with hyperosmolar drops and glyceraldehyde drops, respectively; the right eyes in Group E were instilled with both hyperosmolar drops and glyceraldehyde drops. Central corneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group. Results. Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, and E at 7 d postoperatively (P<0.05) and in Groups C, D, and E at 14 d postoperatively (P<0.05). Conclusion. Chemical CXL technique using glyceraldehyde improved the CCT and corneal transparency of the rabbit bullous keratopathy models. Topical instillation with glyceraldehyde and hyperosmolar solutions seems to be a good choice for the bullous keratopathy treatment.http://dx.doi.org/10.1155/2015/171690 |
| spellingShingle | Mengmeng Wang Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model Journal of Ophthalmology |
| title | Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model |
| title_full | Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model |
| title_fullStr | Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model |
| title_full_unstemmed | Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model |
| title_short | Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model |
| title_sort | effect of glyceraldehyde cross linking on a rabbit bullous keratopathy model |
| url | http://dx.doi.org/10.1155/2015/171690 |
| work_keys_str_mv | AT mengmengwang effectofglyceraldehydecrosslinkingonarabbitbullouskeratopathymodel |