Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System
We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocompo...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/104246 |
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| author | Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir Hussein Sharida Fakurazi |
| author_facet | Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir Hussein Sharida Fakurazi |
| author_sort | Aminu Umar Kura |
| collection | DOAJ |
| description | We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay). |
| format | Article |
| id | doaj-art-9b464b1679f446f5bb38ead365111c7f |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9b464b1679f446f5bb38ead365111c7f2025-08-20T02:20:26ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/104246104246Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery SystemAminu Umar Kura0Samer Hasan Hussein-Al-Ali1Mohd Zobir Hussein2Sharida Fakurazi3Laboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, MalaysiaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, MalaysiaMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400 Selangor, MalaysiaLaboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, MalaysiaWe incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay).http://dx.doi.org/10.1155/2014/104246 |
| spellingShingle | Aminu Umar Kura Samer Hasan Hussein-Al-Ali Mohd Zobir Hussein Sharida Fakurazi Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System The Scientific World Journal |
| title | Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System |
| title_full | Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System |
| title_fullStr | Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System |
| title_full_unstemmed | Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System |
| title_short | Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System |
| title_sort | preparation of tween 80 zn al levodopa layered double hydroxides nanocomposite for drug delivery system |
| url | http://dx.doi.org/10.1155/2014/104246 |
| work_keys_str_mv | AT aminuumarkura preparationoftween80znallevodopalayereddoublehydroxidesnanocompositefordrugdeliverysystem AT samerhasanhusseinalali preparationoftween80znallevodopalayereddoublehydroxidesnanocompositefordrugdeliverysystem AT mohdzobirhussein preparationoftween80znallevodopalayereddoublehydroxidesnanocompositefordrugdeliverysystem AT sharidafakurazi preparationoftween80znallevodopalayereddoublehydroxidesnanocompositefordrugdeliverysystem |