Cardiac toxicity of fluoroquinolones and bedaquiline
The review analyzes data on the impact of fluoroquinolones and bedaquiline on the cardiac conduction system. The dependence of the cardiotoxic effect of fluoroquinolones on their influence on the potassium channels of cardiomyocytes is presented. The article demonstrates the importance of concomitan...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2019-05-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1264 |
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| _version_ | 1850223760600203264 |
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| author | G. N. Mozhokinа A. G. Sаmoylovа |
| author_facet | G. N. Mozhokinа A. G. Sаmoylovа |
| author_sort | G. N. Mozhokinа |
| collection | DOAJ |
| description | The review analyzes data on the impact of fluoroquinolones and bedaquiline on the cardiac conduction system. The dependence of the cardiotoxic effect of fluoroquinolones on their influence on the potassium channels of cardiomyocytes is presented. The article demonstrates the importance of concomitant factors (potassium level in the blood, concurrent heart disorders, a genetically determined amount of HERG receptors in the myocardium, concomitant drug therapy) in the development of the cardiac toxicity caused by fluoroquinolones and bedaquiline. |
| format | Article |
| id | doaj-art-9b423f3cc03048e6bd52e5a4c3874258 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2019-05-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-9b423f3cc03048e6bd52e5a4c38742582025-08-20T02:05:49ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062019-05-01974566210.21292/2075-1230-2019-97-4-56-621264Cardiac toxicity of fluoroquinolones and bedaquilineG. N. Mozhokinа0A. G. Sаmoylovа1National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, RussiaNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, RussiaThe review analyzes data on the impact of fluoroquinolones and bedaquiline on the cardiac conduction system. The dependence of the cardiotoxic effect of fluoroquinolones on their influence on the potassium channels of cardiomyocytes is presented. The article demonstrates the importance of concomitant factors (potassium level in the blood, concurrent heart disorders, a genetically determined amount of HERG receptors in the myocardium, concomitant drug therapy) in the development of the cardiac toxicity caused by fluoroquinolones and bedaquiline.https://www.tibl-journal.com/jour/article/view/1264cardiac toxicityqt intervalfluoroquinolonesbedaquiline |
| spellingShingle | G. N. Mozhokinа A. G. Sаmoylovа Cardiac toxicity of fluoroquinolones and bedaquiline Туберкулез и болезни лёгких cardiac toxicity qt interval fluoroquinolones bedaquiline |
| title | Cardiac toxicity of fluoroquinolones and bedaquiline |
| title_full | Cardiac toxicity of fluoroquinolones and bedaquiline |
| title_fullStr | Cardiac toxicity of fluoroquinolones and bedaquiline |
| title_full_unstemmed | Cardiac toxicity of fluoroquinolones and bedaquiline |
| title_short | Cardiac toxicity of fluoroquinolones and bedaquiline |
| title_sort | cardiac toxicity of fluoroquinolones and bedaquiline |
| topic | cardiac toxicity qt interval fluoroquinolones bedaquiline |
| url | https://www.tibl-journal.com/jour/article/view/1264 |
| work_keys_str_mv | AT gnmozhokina cardiactoxicityoffluoroquinolonesandbedaquiline AT agsamoylova cardiactoxicityoffluoroquinolonesandbedaquiline |