Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer
ABSTRACT Background To evaluate the target localization accuracy of image registration methods in cone beam computed tomography (CBCT)‐based image guidance (IG) for lung stereotactic body radiation therapy (SBRT) and the associations with tumor characteristics such as size, mobility, and location. M...
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| Format: | Article |
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Wiley
2025-08-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.70147 |
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| author | Seong Soon Jang Na‐Young An Hee Kyung Kim Youngjun Yang Gil Ja Huh Joon Won Jeong |
| author_facet | Seong Soon Jang Na‐Young An Hee Kyung Kim Youngjun Yang Gil Ja Huh Joon Won Jeong |
| author_sort | Seong Soon Jang |
| collection | DOAJ |
| description | ABSTRACT Background To evaluate the target localization accuracy of image registration methods in cone beam computed tomography (CBCT)‐based image guidance (IG) for lung stereotactic body radiation therapy (SBRT) and the associations with tumor characteristics such as size, mobility, and location. Methods Four methods involving different matching axes and regions were used to register the planning CT and 3D CBCT images of 36 lung tumors treated with SBRT. The registration axes were divided into 3D translational axes and 6D axes (translational and rotational axes), and the regions were divided into wide rectangular (WR) volume‐of‐interest (VOI) and tumor‐focused (TF) VOI, consisting of the internal target volume (ITV) plus a 1 cm margin. Results Compared with the WR registrations, the TF registrations yielded higher localization accuracies for all registration pairs, with differences of 6.3%–9.1% in the percentage of inclusion of the registered CBCT gross tumor volume (GTV) into the ITV and 1.3–1.8 mm in the 3D distance between the ITV and registered CBCT GTV centroids. The TF3D and TF6D registrations yielded similar accuracy metrics of 91.9% and 1.4 mm, respectively, whereas the WR6D registration exhibited improved accuracies compared with the WR3D registration. The localization accuracies with the TF registrations decreased with increasing tumor mobility index, expressed as the ITV/GTV50% ratio, with significant differences between the tumor groups at a cutoff of 1.7. Conclusions The localization accuracies of our image registration methods may serve as clinically useful references for selecting the most suitable registration in CBCT‐based IG for lung SBRT. |
| format | Article |
| id | doaj-art-9b3d3bc40811445a8e493afcb1f916f2 |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-9b3d3bc40811445a8e493afcb1f916f22025-08-20T03:41:40ZengWileyThoracic Cancer1759-77061759-77142025-08-011615n/an/a10.1111/1759-7714.70147Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung CancerSeong Soon Jang0Na‐Young An1Hee Kyung Kim2Youngjun Yang3Gil Ja Huh4Joon Won Jeong5Department of Radiation Oncology, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Radiation Oncology, Daejeon St. Mary's Hospital Daejeon Republic of KoreaDepartment of Radiology, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Internal Medicine, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Radiation Oncology, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Internal Medicine, College of Medicine The Catholic University of Korea Seoul Republic of KoreaABSTRACT Background To evaluate the target localization accuracy of image registration methods in cone beam computed tomography (CBCT)‐based image guidance (IG) for lung stereotactic body radiation therapy (SBRT) and the associations with tumor characteristics such as size, mobility, and location. Methods Four methods involving different matching axes and regions were used to register the planning CT and 3D CBCT images of 36 lung tumors treated with SBRT. The registration axes were divided into 3D translational axes and 6D axes (translational and rotational axes), and the regions were divided into wide rectangular (WR) volume‐of‐interest (VOI) and tumor‐focused (TF) VOI, consisting of the internal target volume (ITV) plus a 1 cm margin. Results Compared with the WR registrations, the TF registrations yielded higher localization accuracies for all registration pairs, with differences of 6.3%–9.1% in the percentage of inclusion of the registered CBCT gross tumor volume (GTV) into the ITV and 1.3–1.8 mm in the 3D distance between the ITV and registered CBCT GTV centroids. The TF3D and TF6D registrations yielded similar accuracy metrics of 91.9% and 1.4 mm, respectively, whereas the WR6D registration exhibited improved accuracies compared with the WR3D registration. The localization accuracies with the TF registrations decreased with increasing tumor mobility index, expressed as the ITV/GTV50% ratio, with significant differences between the tumor groups at a cutoff of 1.7. Conclusions The localization accuracies of our image registration methods may serve as clinically useful references for selecting the most suitable registration in CBCT‐based IG for lung SBRT.https://doi.org/10.1111/1759-7714.70147image guidanceimage registrationlung cancerstereotactic body radiation therapytarget localization |
| spellingShingle | Seong Soon Jang Na‐Young An Hee Kyung Kim Youngjun Yang Gil Ja Huh Joon Won Jeong Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer Thoracic Cancer image guidance image registration lung cancer stereotactic body radiation therapy target localization |
| title | Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer |
| title_full | Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer |
| title_fullStr | Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer |
| title_full_unstemmed | Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer |
| title_short | Target Localization Accuracy of Image Registrations in Cone Beam Computed Tomography‐Guided Stereotactic Body Radiation Therapy for Lung Cancer |
| title_sort | target localization accuracy of image registrations in cone beam computed tomography guided stereotactic body radiation therapy for lung cancer |
| topic | image guidance image registration lung cancer stereotactic body radiation therapy target localization |
| url | https://doi.org/10.1111/1759-7714.70147 |
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