Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis
Conclusions: In the context of NSOI, we identify ATP2A3 as a novel contributor to immune-driven pathogenesis. Its significant dysregulation in NSOI tissues relative to healthy controls underscores its potential as a prognostic marker within the inflammatory microenvironment.
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/7061507 |
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| _version_ | 1849687762981093376 |
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| author | Zixuan Wu Xi Long Kang Tan Xiaolei Yao Qinghua Peng |
| author_facet | Zixuan Wu Xi Long Kang Tan Xiaolei Yao Qinghua Peng |
| author_sort | Zixuan Wu |
| collection | DOAJ |
| description | Conclusions: In the context of NSOI, we identify ATP2A3 as a novel contributor to immune-driven pathogenesis. Its significant dysregulation in NSOI tissues relative to healthy controls underscores its potential as a prognostic marker within the inflammatory microenvironment. |
| format | Article |
| id | doaj-art-9b39fd1e1b9947f3a846fd5515f13d1f |
| institution | DOAJ |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9b39fd1e1b9947f3a846fd5515f13d1f2025-08-20T03:22:15ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/7061507Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization AnalysisZixuan Wu0Xi Long1Kang Tan2Xiaolei Yao3Qinghua Peng4Hunan University of Traditional Chinese MedicineHunan University of Traditional Chinese MedicineHunan University of Traditional Chinese MedicineDepartment of OphthalmologyHunan University of Traditional Chinese MedicineConclusions: In the context of NSOI, we identify ATP2A3 as a novel contributor to immune-driven pathogenesis. Its significant dysregulation in NSOI tissues relative to healthy controls underscores its potential as a prognostic marker within the inflammatory microenvironment.http://dx.doi.org/10.1155/mi/7061507 |
| spellingShingle | Zixuan Wu Xi Long Kang Tan Xiaolei Yao Qinghua Peng Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis Mediators of Inflammation |
| title | Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis |
| title_full | Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis |
| title_fullStr | Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis |
| title_full_unstemmed | Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis |
| title_short | Immune Regulation and ECM-Related Pathway Enrichment Reveal ATP2A3 as a Prognostic Biomarker for Nonspecific Orbital Inflammation: An Integrated Machine Learning and Mendelian Randomization Analysis |
| title_sort | immune regulation and ecm related pathway enrichment reveal atp2a3 as a prognostic biomarker for nonspecific orbital inflammation an integrated machine learning and mendelian randomization analysis |
| url | http://dx.doi.org/10.1155/mi/7061507 |
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