Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke
Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/2602871 |
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| _version_ | 1850170666083418112 |
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| author | Pian Gong Wei Zhang Yan He Jianfeng Wang Song Li Songyu Chen Qingsong Ye Mingchang Li |
| author_facet | Pian Gong Wei Zhang Yan He Jianfeng Wang Song Li Songyu Chen Qingsong Ye Mingchang Li |
| author_sort | Pian Gong |
| collection | DOAJ |
| description | Ischemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment. |
| format | Article |
| id | doaj-art-9b35ddfd9eef4821a914f8d59213cbc1 |
| institution | OA Journals |
| issn | 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9b35ddfd9eef4821a914f8d59213cbc12025-08-20T02:20:26ZengWileyStem Cells International1687-96782021-01-01202110.1155/2021/2602871Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic StrokePian Gong0Wei Zhang1Yan He2Jianfeng Wang3Song Li4Songyu Chen5Qingsong Ye6Mingchang Li7Department of NeurosurgeryDepartment of NeurosurgeryRegenerative Medicine LabDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurosurgeryCenter of Regenerative MedicineDepartment of NeurosurgeryIschemic stroke is a serious cerebral disease that often induces death and long-term disability. As a currently available therapy for recanalization after ischemic stroke, thrombolysis, including intravenous thrombolysis and endovascular therapy, still cannot be applicable to all patients due to the narrow time window. Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke. MSC transplantation therapy has exhibited its potential to improve the neurological function in ischemic stroke. Our review describes the current progress and future perspective of MSC transplantation therapy in ischemic stroke treatment, including cell types, transplantation approaches, therapeutic mechanisms, and preliminary clinical trials of MSC transplantation, for providing us an update role of MSC transplantation in ischemic stroke treatment.http://dx.doi.org/10.1155/2021/2602871 |
| spellingShingle | Pian Gong Wei Zhang Yan He Jianfeng Wang Song Li Songyu Chen Qingsong Ye Mingchang Li Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke Stem Cells International |
| title | Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke |
| title_full | Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke |
| title_fullStr | Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke |
| title_full_unstemmed | Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke |
| title_short | Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke |
| title_sort | classification and characteristics of mesenchymal stem cells and its potential therapeutic mechanisms and applications against ischemic stroke |
| url | http://dx.doi.org/10.1155/2021/2602871 |
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