Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice
Summary: The hippocampus, a critical brain structure for spatial learning and memory, is susceptible to neurodegenerative disorders such as Alzheimer’s disease (AD). Utilizing APPswe/PSEN1dE9 (APP/PS1) mice, we investigated neurophysiological mechanisms underlying AD-associated cognitive impairments...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422402858X |
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| author | Sanggeon Park Mijeong Park Eun Joo Kim Jeansok J. Kim Jeiwon Cho Yeowool Huh |
| author_facet | Sanggeon Park Mijeong Park Eun Joo Kim Jeansok J. Kim Jeiwon Cho Yeowool Huh |
| author_sort | Sanggeon Park |
| collection | DOAJ |
| description | Summary: The hippocampus, a critical brain structure for spatial learning and memory, is susceptible to neurodegenerative disorders such as Alzheimer’s disease (AD). Utilizing APPswe/PSEN1dE9 (APP/PS1) mice, we investigated neurophysiological mechanisms underlying AD-associated cognitive impairments by assessing place cell activities in CA1 and CA3 hippocampal subregions, which have distinct yet complementary computational roles. Analyses revealed significant deterioration in spatial representation capabilities of APP/PS1 relative to wild-type (WT) mice. Specifically, CA1 place cells exhibited reduction in coherence and spatial information, while CA3 place cells displayed reduction in place field size. Place cells in both subregions showed disruption in stability and burst firing properties. Furthermore, theta rhythm was significantly attenuated in CA1 place cells of APP/PS1 mice. These findings elucidate that distinct physiological perturbations in CA1 and CA3 place cells, coupled with disrupted hippocampal theta rhythmicity in CA1, potentially orchestrate the impairment of hippocampal-dependent spatial learning and memory in AD pathogenesis. |
| format | Article |
| id | doaj-art-9b34ffedee17483a90b0587c3ac988d7 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-9b34ffedee17483a90b0587c3ac988d72025-01-24T04:45:34ZengElsevieriScience2589-00422025-02-01282111631Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease miceSanggeon Park0Mijeong Park1Eun Joo Kim2Jeansok J. Kim3Jeiwon Cho4Yeowool Huh5Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul, Republic of KoreaCenter for Neural Science, Korea Institute of Science and Technology, Seoul 136-791, Republic of KoreaDepartment of Psychology, University of Washington, Seattle, WA, USADepartment of Psychology, University of Washington, Seattle, WA, USADepartment of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul, Republic of Korea; Corresponding authorInstitute for Bio-Medical Convergence, International St. Mary’s Hospital, Catholic Kwandong University, Incheon, Republic of Korea; Department of Medical Science, College of Medicine, Catholic Kwandong University, Gangneung, Republic of Korea; Corresponding authorSummary: The hippocampus, a critical brain structure for spatial learning and memory, is susceptible to neurodegenerative disorders such as Alzheimer’s disease (AD). Utilizing APPswe/PSEN1dE9 (APP/PS1) mice, we investigated neurophysiological mechanisms underlying AD-associated cognitive impairments by assessing place cell activities in CA1 and CA3 hippocampal subregions, which have distinct yet complementary computational roles. Analyses revealed significant deterioration in spatial representation capabilities of APP/PS1 relative to wild-type (WT) mice. Specifically, CA1 place cells exhibited reduction in coherence and spatial information, while CA3 place cells displayed reduction in place field size. Place cells in both subregions showed disruption in stability and burst firing properties. Furthermore, theta rhythm was significantly attenuated in CA1 place cells of APP/PS1 mice. These findings elucidate that distinct physiological perturbations in CA1 and CA3 place cells, coupled with disrupted hippocampal theta rhythmicity in CA1, potentially orchestrate the impairment of hippocampal-dependent spatial learning and memory in AD pathogenesis.http://www.sciencedirect.com/science/article/pii/S258900422402858XMolecular biologyNeuroscience |
| spellingShingle | Sanggeon Park Mijeong Park Eun Joo Kim Jeansok J. Kim Jeiwon Cho Yeowool Huh Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice iScience Molecular biology Neuroscience |
| title | Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice |
| title_full | Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice |
| title_fullStr | Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice |
| title_full_unstemmed | Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice |
| title_short | Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice |
| title_sort | distinct disruptions in ca1 and ca3 place cell function in alzheimer s disease mice |
| topic | Molecular biology Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S258900422402858X |
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