Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
Granular cell tumors (GCTs) are rare, benign tumors typically originating from Schwann cells, with the head and neck being the most common sites. Laryngeal GCTs, particularly those affecting the vocal cords, are exceedingly rare in adults. This report presents a 28-year-old female with a GCT of the...
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De Gruyter
2025-08-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1250 |
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| author | Bukhari Manal |
| author_facet | Bukhari Manal |
| author_sort | Bukhari Manal |
| collection | DOAJ |
| description | Granular cell tumors (GCTs) are rare, benign tumors typically originating from Schwann cells, with the head and neck being the most common sites. Laryngeal GCTs, particularly those affecting the vocal cords, are exceedingly rare in adults. This report presents a 28-year-old female with a GCT of the left vocal cord extending into the subglottic region. The patient presented with progressive dysphonia, and laryngoscopy revealed a 2 cm × 1 cm mass on the left vocal cord. Microlaryngeal examination confirmed subglottic extension, and the tumor was excised using carbon dioxide (CO2) laser. Histopathological analysis confirmed GCT with S100 positivity. Two months later, the patient developed a late complication – granuloma formation at the excision site – necessitating revision surgery. The patient was symptom-free at the 12-month follow-up. GCTs in the vocal cords with subglottic extension are rare and challenging to diagnose and treat. They are generally benign lesions and rarely undergo malignant transformation. Diagnosis is confirmed through histology, and treatment involves wide local excision, with re-excision needed for recurrence. GCTs are chemo- and radio-insensitive, making surgery the primary treatment. This case underscores the importance of accurate diagnosis and tailored treatment, highlighting the need for further research on this rare condition. |
| format | Article |
| id | doaj-art-9b315266fb474308b32ba2cd89c33f6f |
| institution | Kabale University |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-9b315266fb474308b32ba2cd89c33f6f2025-08-20T03:41:43ZengDe GruyterOpen Medicine2391-54632025-08-012019365410.1515/med-2025-1250Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case reportBukhari Manal0Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi ArabiaGranular cell tumors (GCTs) are rare, benign tumors typically originating from Schwann cells, with the head and neck being the most common sites. Laryngeal GCTs, particularly those affecting the vocal cords, are exceedingly rare in adults. This report presents a 28-year-old female with a GCT of the left vocal cord extending into the subglottic region. The patient presented with progressive dysphonia, and laryngoscopy revealed a 2 cm × 1 cm mass on the left vocal cord. Microlaryngeal examination confirmed subglottic extension, and the tumor was excised using carbon dioxide (CO2) laser. Histopathological analysis confirmed GCT with S100 positivity. Two months later, the patient developed a late complication – granuloma formation at the excision site – necessitating revision surgery. The patient was symptom-free at the 12-month follow-up. GCTs in the vocal cords with subglottic extension are rare and challenging to diagnose and treat. They are generally benign lesions and rarely undergo malignant transformation. Diagnosis is confirmed through histology, and treatment involves wide local excision, with re-excision needed for recurrence. GCTs are chemo- and radio-insensitive, making surgery the primary treatment. This case underscores the importance of accurate diagnosis and tailored treatment, highlighting the need for further research on this rare condition.https://doi.org/10.1515/med-2025-1250abrikossoff’s tumordysphoniagranular cell tumorlaryngeal neoplasm |
| spellingShingle | Bukhari Manal Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report Open Medicine abrikossoff’s tumor dysphonia granular cell tumor laryngeal neoplasm |
| title | Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report |
| title_full | Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report |
| title_fullStr | Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report |
| title_full_unstemmed | Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report |
| title_short | Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report |
| title_sort | laser excision of a large granular cell tumor of the vocal cord with subglottic extension a case report |
| topic | abrikossoff’s tumor dysphonia granular cell tumor laryngeal neoplasm |
| url | https://doi.org/10.1515/med-2025-1250 |
| work_keys_str_mv | AT bukharimanal laserexcisionofalargegranularcelltumorofthevocalcordwithsubglotticextensionacasereport |