Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity
Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is de...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/7395239 |
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| author | Yuewen Wang Xu Chao Fiaz ud Din Ahmad Hailong Shi Hania Mehboob Waseem Hassan |
| author_facet | Yuewen Wang Xu Chao Fiaz ud Din Ahmad Hailong Shi Hania Mehboob Waseem Hassan |
| author_sort | Yuewen Wang |
| collection | DOAJ |
| description | Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect of Phoenix dactylifera extract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity. Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days. Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA. Subsequently, DOX initiated changes in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE. PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity. Groups treated with different doses of PDE showed marked decrease in levels of cardiac and renal markers. The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity. |
| format | Article |
| id | doaj-art-9b2ca3ca946b445c982fa69c7cca8e3a |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-9b2ca3ca946b445c982fa69c7cca8e3a2025-08-20T02:20:25ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/73952397395239Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and NephrotoxicityYuewen Wang0Xu Chao1Fiaz ud Din Ahmad2Hailong Shi3Hania Mehboob4Waseem Hassan5School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, ChinaSchool of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, ChinaDepartment of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, PakistanSchool of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, ChinaDepartment of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, PakistanDepartment of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 54000, PakistanDoxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect of Phoenix dactylifera extract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity. Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days. Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA. Subsequently, DOX initiated changes in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE. PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity. Groups treated with different doses of PDE showed marked decrease in levels of cardiac and renal markers. The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity.http://dx.doi.org/10.1155/2019/7395239 |
| spellingShingle | Yuewen Wang Xu Chao Fiaz ud Din Ahmad Hailong Shi Hania Mehboob Waseem Hassan Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity Cardiology Research and Practice |
| title | Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity |
| title_full | Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity |
| title_fullStr | Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity |
| title_full_unstemmed | Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity |
| title_short | Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity |
| title_sort | phoenix dactylifera protects against doxorubicin induced cardiotoxicity and nephrotoxicity |
| url | http://dx.doi.org/10.1155/2019/7395239 |
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