Monocytes/macrophages karyologic indices in patients with chronic heart failure
Genetic factors impact in chronic heart failure (HF) development is discussed during last decades. The aim was to evaluate cytogenetic status of patients with ischemic HF with karyologic analyzes of monocytes/macrophages. Methods and results. 24 patients and 12 practically healthy persons (con...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/38735/35084 |
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| author | S. V. Fedorov L. Ye. Kovalchuk |
| author_facet | S. V. Fedorov L. Ye. Kovalchuk |
| author_sort | S. V. Fedorov |
| collection | DOAJ |
| description | Genetic factors impact in chronic heart failure (HF) development is discussed during last decades.
The aim was to evaluate cytogenetic status of patients with ischemic HF with karyologic analyzes of monocytes/macrophages.
Methods and results. 24 patients and 12 practically healthy persons (control group) were included into the study. Internuclear bridges, perinulcear vacuolization, vacuolization and nuclear chromatin condensation were detected more frequent in patients with HF than in control.
Conclusion. This indicates proliferation activation and is initial signs of apoptosis/necrosis in observed cells. |
| format | Article |
| id | doaj-art-9b2c5b5fbce94d61bc4bb538db2fe9c0 |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-9b2c5b5fbce94d61bc4bb538db2fe9c02025-08-20T03:19:41ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-02-0113133http://dx.doi.org/10.14739/2310-1210.2015.1.38735Monocytes/macrophages karyologic indices in patients with chronic heart failureS. V. Fedorov L. Ye. KovalchukGenetic factors impact in chronic heart failure (HF) development is discussed during last decades. The aim was to evaluate cytogenetic status of patients with ischemic HF with karyologic analyzes of monocytes/macrophages. Methods and results. 24 patients and 12 practically healthy persons (control group) were included into the study. Internuclear bridges, perinulcear vacuolization, vacuolization and nuclear chromatin condensation were detected more frequent in patients with HF than in control. Conclusion. This indicates proliferation activation and is initial signs of apoptosis/necrosis in observed cells.http://zmj.zsmu.edu.ua/article/view/38735/35084Heart FailureCytogenetic AnalysisMonocytesMacrophages |
| spellingShingle | S. V. Fedorov L. Ye. Kovalchuk Monocytes/macrophages karyologic indices in patients with chronic heart failure Zaporožskij Medicinskij Žurnal Heart Failure Cytogenetic Analysis Monocytes Macrophages |
| title | Monocytes/macrophages karyologic indices in patients with chronic heart failure |
| title_full | Monocytes/macrophages karyologic indices in patients with chronic heart failure |
| title_fullStr | Monocytes/macrophages karyologic indices in patients with chronic heart failure |
| title_full_unstemmed | Monocytes/macrophages karyologic indices in patients with chronic heart failure |
| title_short | Monocytes/macrophages karyologic indices in patients with chronic heart failure |
| title_sort | monocytes macrophages karyologic indices in patients with chronic heart failure |
| topic | Heart Failure Cytogenetic Analysis Monocytes Macrophages |
| url | http://zmj.zsmu.edu.ua/article/view/38735/35084 |
| work_keys_str_mv | AT svfedorov monocytesmacrophageskaryologicindicesinpatientswithchronicheartfailure AT lyekovalchuk monocytesmacrophageskaryologicindicesinpatientswithchronicheartfailure |