Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis
Objective. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods. In across-sectional study, 39 RA-ILD patients confirmed by high...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/151626 |
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| author | Alberto Daniel Rocha-Muñoz Manuel Ponce-Guarneros Jorge Ivan Gamez-Nava Eva Maria Olivas-Flores Mayra Mejía Pablo Juárez-Contreras Erika Aurora Martínez-García Esther Guadalupe Corona-Sánchez Tania Marlen Rodríguez-Hernández Mónica Vázquez-del Mercado Mario Salazar-Páramo Arnulfo Hernan Nava-Zavala Ernesto German Cardona-Muñoz Alfredo Celis Laura González-Lopez |
| author_facet | Alberto Daniel Rocha-Muñoz Manuel Ponce-Guarneros Jorge Ivan Gamez-Nava Eva Maria Olivas-Flores Mayra Mejía Pablo Juárez-Contreras Erika Aurora Martínez-García Esther Guadalupe Corona-Sánchez Tania Marlen Rodríguez-Hernández Mónica Vázquez-del Mercado Mario Salazar-Páramo Arnulfo Hernan Nava-Zavala Ernesto German Cardona-Muñoz Alfredo Celis Laura González-Lopez |
| author_sort | Alberto Daniel Rocha-Muñoz |
| collection | DOAJ |
| description | Objective. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods. In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified. Results. Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P<0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P=0.003) and + RF (P=0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P=0.02) and with fibrosis score DD (P=0.01), anti-CCP2 titers (P<0.001), and MTX treatment duration (P<0.001). Conclusions. Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD. |
| format | Article |
| id | doaj-art-9b28fc9ce8a545768d46e352d37ef045 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-9b28fc9ce8a545768d46e352d37ef0452025-02-03T07:25:32ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/151626151626Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid ArthritisAlberto Daniel Rocha-Muñoz0Manuel Ponce-Guarneros1Jorge Ivan Gamez-Nava2Eva Maria Olivas-Flores3Mayra Mejía4Pablo Juárez-Contreras5Erika Aurora Martínez-García6Esther Guadalupe Corona-Sánchez7Tania Marlen Rodríguez-Hernández8Mónica Vázquez-del Mercado9Mario Salazar-Páramo10Arnulfo Hernan Nava-Zavala11Ernesto German Cardona-Muñoz12Alfredo Celis13Laura González-Lopez14Centro Universitario de Tonalá (CUTONALA), Universidad de Guadalajara (U de G), 48525 Tonala, JAL, MexicoPrograma de Becarios de Investigación del Instituto Mexicano del Seguro Social (IMSS) y Programa de Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), U de G, 44340 Guadalajara, JAL, MexicoUnidad de Investigación en Epidemiología Clínica y División de Investigación en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, MexicoHospital General Regional-180, IMSS, 45650 Tlajomulco, JAL, MexicoInstituto Nacional de Enfermedades Respiratorias “Dr. Ismael Cosío Villegas” (INER), 14080 Mexico City, DF, MexicoDepartamento de Medicina Interna-Reumatología y Departamento de Medicina Interna-Neumología, HGR-110, IMSS, 44700 Guadalajara, JAL, MexicoDepartamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, MexicoDepartamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, MexicoPrograma de Servicio Social en Investigación, Secretaria de Salud (SSA), 11570 Mexico City, DF, MexicoInstituto de Investigacion en Reumatologia y del Sistema Musculoesqueletico, CUCS and Division de Medicina Interna, Servicio de Reumatologia OPD Hospital Civil Dr. Juan I Menchaca, U de G, 44340 Guadalajara, JAL, MexicoUnidad de Investigación en Epidemiología Clínica y División de Investigación en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, MexicoUnidad de Investigación en Epidemiología Clínica y División de Investigación en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, MexicoDepartamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, MexicoPrograma de Doctorado en Salud Pública, CUCS, U de G, 44340 Guadalajara, JAL, MexicoPrograma de Doctorado en Salud Pública, CUCS, U de G, 44340 Guadalajara, JAL, MexicoObjective. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods. In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified. Results. Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P<0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P=0.003) and + RF (P=0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P=0.02) and with fibrosis score DD (P=0.01), anti-CCP2 titers (P<0.001), and MTX treatment duration (P<0.001). Conclusions. Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD.http://dx.doi.org/10.1155/2015/151626 |
| spellingShingle | Alberto Daniel Rocha-Muñoz Manuel Ponce-Guarneros Jorge Ivan Gamez-Nava Eva Maria Olivas-Flores Mayra Mejía Pablo Juárez-Contreras Erika Aurora Martínez-García Esther Guadalupe Corona-Sánchez Tania Marlen Rodríguez-Hernández Mónica Vázquez-del Mercado Mario Salazar-Páramo Arnulfo Hernan Nava-Zavala Ernesto German Cardona-Muñoz Alfredo Celis Laura González-Lopez Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis Journal of Immunology Research |
| title | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
| title_full | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
| title_fullStr | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
| title_full_unstemmed | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
| title_short | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
| title_sort | anti cyclic citrullinated peptide antibodies and severity of interstitial lung disease in women with rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2015/151626 |
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