Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex
22-year-old male diagnosed with Tuberous Sclerosis Complex (TSC), a genetic disorder characterized by benign tumors in various organs, with a focus on neurological implications. Central to the study is the development of Subependymal Giant Cell Astrocytomas (SEGAs), leading to hydrocephalus in the...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2024-05-01
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| Series: | Acta Medica Lituanica |
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| Online Access: | https://www.journals.vu.lt/AML/article/view/34418 |
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| _version_ | 1832593387239243776 |
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| author | Antonio Navarro-Ballester Rosa Álvaro-Ballester Miguel Ángel Lara-Martínez |
| author_facet | Antonio Navarro-Ballester Rosa Álvaro-Ballester Miguel Ángel Lara-Martínez |
| author_sort | Antonio Navarro-Ballester |
| collection | DOAJ |
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22-year-old male diagnosed with Tuberous Sclerosis Complex (TSC), a genetic disorder characterized by benign tumors in various organs, with a focus on neurological implications. Central to the study is the development of Subependymal Giant Cell Astrocytomas (SEGAs), leading to hydrocephalus in the patient. The diagnosis of TSC was made in the patient’s childhood, and he was monitored regularly. The study highlights a significant growth in a subependymal nodule, leading to monoventricular hydrocephalus. MRI scans played a crucial role in identifying the progression of SEGAs and the subsequent hydrocephalus. The treatment approach involved endoscopic surgical removal of the SEGA, with histopathology confirming the diagnosis. Post-surgical outcomes over an eight-year follow-up period showed a normalization in ventricular size and the stability of other subependymal nodules, without any complications. This case underscores the importance of regular monitoring for TSC patients, early intervention for complications like hydrocephalus, and the need for a multidisciplinary treatment approach. The case study provides valuable insights into the management of neurodevelopmental disorders and the complexities surrounding TSC and SEGAs.
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| format | Article |
| id | doaj-art-9b289927f02f43eaab472fcc342b2192 |
| institution | Kabale University |
| issn | 1392-0138 2029-4174 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Acta Medica Lituanica |
| spelling | doaj-art-9b289927f02f43eaab472fcc342b21922025-01-20T18:07:58ZengVilnius University PressActa Medica Lituanica1392-01382029-41742024-05-0131110.15388/Amed.2024.31.1.9Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis ComplexAntonio Navarro-Ballester0https://orcid.org/0000-0003-1684-5473Rosa Álvaro-Ballester1Miguel Ángel Lara-Martínez2Radiology Department, Hospital General Universitari de Castelló, Castellón de la Plana (Castellón), SpainRadiology Department, Hospital General Universitari de Castelló, Castellón de la Plana (Castellón), SpainRadiology Department, Hospital General Universitari de Castelló, Castellón de la Plana (Castellón), Spain 22-year-old male diagnosed with Tuberous Sclerosis Complex (TSC), a genetic disorder characterized by benign tumors in various organs, with a focus on neurological implications. Central to the study is the development of Subependymal Giant Cell Astrocytomas (SEGAs), leading to hydrocephalus in the patient. The diagnosis of TSC was made in the patient’s childhood, and he was monitored regularly. The study highlights a significant growth in a subependymal nodule, leading to monoventricular hydrocephalus. MRI scans played a crucial role in identifying the progression of SEGAs and the subsequent hydrocephalus. The treatment approach involved endoscopic surgical removal of the SEGA, with histopathology confirming the diagnosis. Post-surgical outcomes over an eight-year follow-up period showed a normalization in ventricular size and the stability of other subependymal nodules, without any complications. This case underscores the importance of regular monitoring for TSC patients, early intervention for complications like hydrocephalus, and the need for a multidisciplinary treatment approach. The case study provides valuable insights into the management of neurodevelopmental disorders and the complexities surrounding TSC and SEGAs. https://www.journals.vu.lt/AML/article/view/34418GliomaTuberous SclerosisHydrocephalus |
| spellingShingle | Antonio Navarro-Ballester Rosa Álvaro-Ballester Miguel Ángel Lara-Martínez Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex Acta Medica Lituanica Glioma Tuberous Sclerosis Hydrocephalus |
| title | Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex |
| title_full | Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex |
| title_fullStr | Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex |
| title_full_unstemmed | Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex |
| title_short | Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex |
| title_sort | beyond benign a case of subependymal giant cell astrocytomas provoking hydrocephalus in tuberous sclerosis complex |
| topic | Glioma Tuberous Sclerosis Hydrocephalus |
| url | https://www.journals.vu.lt/AML/article/view/34418 |
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