An Inducible CYP19A1 Excision Model for Sexual Differentiation in Chicken (<i>Gallus gallus</i>) via the CRISPR/Cas9 System

An Inducible CYP19A1 Excision Model for Sexual Differentiation in Chicken (<i>Gallus gallus</i>) via the CRISPR/Cas9 System

Aromatase, a crucial enzyme for estrogen synthesis, plays a vital role in gender determination and differentiation. This study aimed to establish an inducible knockout model of the chicken <i>CYP19A1</i> gene, which encodes aromatase, to support gender control in chickens. We selected th...

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Bibliographic Details
Main Authors: Guangzheng Liu, Yixiu Peng, Zeyu Li, Xilin Zhu, Hongyan Sun, Guohong Chen, Qisheng Zuo, Yingjie Niu, Jiuzhou Song, Wei Han, Wanhong Wei, Bichun Li, Kai Jin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Veterinary Sciences
Subjects:
chickens
gene knockout
gender control
CRISPR/Cas9
Tet-on
Online Access:https://www.mdpi.com/2306-7381/12/4/296
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