Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297
In response to phage infection, bacteria have evolved a variety of sophisticated immune defense systems to combat viral predation. Among these defense mechanisms, the transmission of immune signals via intracellular signal transduction molecules is a common strategy that often accompanies enzyme act...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1612006/full |
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| author | Xiaoyan Wang Xiaoyan Wang Leiliang Zhang Leiliang Zhang |
| author_facet | Xiaoyan Wang Xiaoyan Wang Leiliang Zhang Leiliang Zhang |
| author_sort | Xiaoyan Wang |
| collection | DOAJ |
| description | In response to phage infection, bacteria have evolved a variety of sophisticated immune defense systems to combat viral predation. Among these defense mechanisms, the transmission of immune signals via intracellular signal transduction molecules is a common strategy that often accompanies enzyme activity. Recent studies have characterized the HerA-DUF4297 protein complex, a two-component defense system that integrates ATPase and nuclease activities. This complex inhibits phage infection by inducing DNA degradation. Notably, DUF4297 displays minimal nuclease activity when it operates on its own. However, it demonstrates robust nuclease activity when in complex with HerA. Crucially, the nuclease activity within this complex is regulated by structural changes. These findings provide novel insights into the activation of bacterial immune systems against phages, suggesting that the architectural remodeling of protein complexes can serve as a mechanism for transmitting immune signals. |
| format | Article |
| id | doaj-art-9b1f4610e3104af58d26ff1a875d5a1b |
| institution | OA Journals |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-9b1f4610e3104af58d26ff1a875d5a1b2025-08-20T02:23:00ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.16120061612006Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297Xiaoyan Wang0Xiaoyan Wang1Leiliang Zhang2Leiliang Zhang3Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaIn response to phage infection, bacteria have evolved a variety of sophisticated immune defense systems to combat viral predation. Among these defense mechanisms, the transmission of immune signals via intracellular signal transduction molecules is a common strategy that often accompanies enzyme activity. Recent studies have characterized the HerA-DUF4297 protein complex, a two-component defense system that integrates ATPase and nuclease activities. This complex inhibits phage infection by inducing DNA degradation. Notably, DUF4297 displays minimal nuclease activity when it operates on its own. However, it demonstrates robust nuclease activity when in complex with HerA. Crucially, the nuclease activity within this complex is regulated by structural changes. These findings provide novel insights into the activation of bacterial immune systems against phages, suggesting that the architectural remodeling of protein complexes can serve as a mechanism for transmitting immune signals.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1612006/fullHerA-DUF4297structural remodelingphagebacterial immunitynuclease |
| spellingShingle | Xiaoyan Wang Xiaoyan Wang Leiliang Zhang Leiliang Zhang Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 Frontiers in Cellular and Infection Microbiology HerA-DUF4297 structural remodeling phage bacterial immunity nuclease |
| title | Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 |
| title_full | Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 |
| title_fullStr | Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 |
| title_full_unstemmed | Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 |
| title_short | Structural remodeling activates bacterial anti-phage immunity: insights from HerA-DUF4297 |
| title_sort | structural remodeling activates bacterial anti phage immunity insights from hera duf4297 |
| topic | HerA-DUF4297 structural remodeling phage bacterial immunity nuclease |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1612006/full |
| work_keys_str_mv | AT xiaoyanwang structuralremodelingactivatesbacterialantiphageimmunityinsightsfromheraduf4297 AT xiaoyanwang structuralremodelingactivatesbacterialantiphageimmunityinsightsfromheraduf4297 AT leiliangzhang structuralremodelingactivatesbacterialantiphageimmunityinsightsfromheraduf4297 AT leiliangzhang structuralremodelingactivatesbacterialantiphageimmunityinsightsfromheraduf4297 |