Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis
Abstract Background Gamma-glutamyl transpeptidase (GGT) is an important molecule produced by hepatocytes that has been noticed as a prooxidative enzyme. GGT has been found to be included in the inflammation process and oxidative damage in multiple diseases in human. Psoriatic arthritis (PsA) is an i...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-11-01
|
| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-024-00291-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850216447011192832 |
|---|---|
| author | Wafaa Soliman Nada Adel Aya Safar |
| author_facet | Wafaa Soliman Nada Adel Aya Safar |
| author_sort | Wafaa Soliman |
| collection | DOAJ |
| description | Abstract Background Gamma-glutamyl transpeptidase (GGT) is an important molecule produced by hepatocytes that has been noticed as a prooxidative enzyme. GGT has been found to be included in the inflammation process and oxidative damage in multiple diseases in human. Psoriatic arthritis (PsA) is an inflammatory disorder leading to high mortality and morbidity due to cardiovascular events. However, GGT role in PsA remains unclear. The aim of this study is to determine the association of GGT with PsA activity and atherosclerosis in PsA patients. Also, to investigate if GGT can serve as an indicator of subclinical atherosclerosis in PsA patients. Results This study was performed on 30 PsA patients and 30 matched healthy subjects. All patients underwent detailed history taking and clinical assessment. Disease activity in PsA (DAPSA) score was used to assess disease activity in PsA patients. GGT level in serum was quantified by utilizing enzyme-linked immunosorbent assay and correlated with carotid intima media thickness (CIMT) and PsA disease activity. Patients’ mean age and disease duration was 43.37 ± 7.65 years (30–55 years) and 7.97 ± 4.214 years (2–15 years) respectively. Levels of GGT in serum were significantly increased in patients compared to GGT serum levels in controls (p < 0.001). Serum GGT levels showed significant positive correlation with DAPSA score, LDL, cholesterol triglycerides, and right and left CIMT (r = 0.913, 0.587, 0.779, 0.803, 0.736, 0.728 and p < 0.001 respectively) and significant negative correlation with HDL (r = − 0.681 and p < 0.001). However, GGT serum levels and PsA disease duration did not show significant correlation. Conclusion Serum GGT was associated with high disease activity, high lipid profile, and large CIMT in PsA patients. GGT might be an indicator of subclinical atherosclerosis and increased disease activity in patients with PsA. |
| format | Article |
| id | doaj-art-9b197de61e7348a8b1d57de35a6e99ce |
| institution | OA Journals |
| issn | 2090-3235 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj-art-9b197de61e7348a8b1d57de35a6e99ce2025-08-20T02:08:19ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352024-11-015111710.1186/s43166-024-00291-4Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritisWafaa Soliman0Nada Adel1Aya Safar2Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Ain Shams UniversityDiagnostic Radiology Department, Faculty of Medicine, Ain Shams UniversityPhysical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Ain Shams UniversityAbstract Background Gamma-glutamyl transpeptidase (GGT) is an important molecule produced by hepatocytes that has been noticed as a prooxidative enzyme. GGT has been found to be included in the inflammation process and oxidative damage in multiple diseases in human. Psoriatic arthritis (PsA) is an inflammatory disorder leading to high mortality and morbidity due to cardiovascular events. However, GGT role in PsA remains unclear. The aim of this study is to determine the association of GGT with PsA activity and atherosclerosis in PsA patients. Also, to investigate if GGT can serve as an indicator of subclinical atherosclerosis in PsA patients. Results This study was performed on 30 PsA patients and 30 matched healthy subjects. All patients underwent detailed history taking and clinical assessment. Disease activity in PsA (DAPSA) score was used to assess disease activity in PsA patients. GGT level in serum was quantified by utilizing enzyme-linked immunosorbent assay and correlated with carotid intima media thickness (CIMT) and PsA disease activity. Patients’ mean age and disease duration was 43.37 ± 7.65 years (30–55 years) and 7.97 ± 4.214 years (2–15 years) respectively. Levels of GGT in serum were significantly increased in patients compared to GGT serum levels in controls (p < 0.001). Serum GGT levels showed significant positive correlation with DAPSA score, LDL, cholesterol triglycerides, and right and left CIMT (r = 0.913, 0.587, 0.779, 0.803, 0.736, 0.728 and p < 0.001 respectively) and significant negative correlation with HDL (r = − 0.681 and p < 0.001). However, GGT serum levels and PsA disease duration did not show significant correlation. Conclusion Serum GGT was associated with high disease activity, high lipid profile, and large CIMT in PsA patients. GGT might be an indicator of subclinical atherosclerosis and increased disease activity in patients with PsA.https://doi.org/10.1186/s43166-024-00291-4Psoriatic arthritisAtherosclerosisCarotid intima media thicknessCIMTDAPSAGamma-glutamyl transpeptidase |
| spellingShingle | Wafaa Soliman Nada Adel Aya Safar Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis Egyptian Rheumatology and Rehabilitation Psoriatic arthritis Atherosclerosis Carotid intima media thickness CIMT DAPSA Gamma-glutamyl transpeptidase |
| title | Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis |
| title_full | Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis |
| title_fullStr | Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis |
| title_full_unstemmed | Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis |
| title_short | Gamma-glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis |
| title_sort | gamma glutamyl transpeptidase as an indicator for subclinical cardiovascular disease in patients with psoriatic arthritis |
| topic | Psoriatic arthritis Atherosclerosis Carotid intima media thickness CIMT DAPSA Gamma-glutamyl transpeptidase |
| url | https://doi.org/10.1186/s43166-024-00291-4 |
| work_keys_str_mv | AT wafaasoliman gammaglutamyltranspeptidaseasanindicatorforsubclinicalcardiovasculardiseaseinpatientswithpsoriaticarthritis AT nadaadel gammaglutamyltranspeptidaseasanindicatorforsubclinicalcardiovasculardiseaseinpatientswithpsoriaticarthritis AT ayasafar gammaglutamyltranspeptidaseasanindicatorforsubclinicalcardiovasculardiseaseinpatientswithpsoriaticarthritis |