Protein restriction in CKD: an outdated strategy in the modern era
Abstract Chronic kidney disease (CKD) management has traditionally emphasized dietary protein restriction to slow disease progression and delay end-stage renal disease (ESRD). However, evidence from trials questions the supposed efficacy of this approach and also highlights potential risks such as m...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2025-02-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100601&lng=en&tlng=en |
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| _version_ | 1823859194576502784 |
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| author | Abdullah Bawazir Joel M Topf Swapnil Hiremath |
| author_facet | Abdullah Bawazir Joel M Topf Swapnil Hiremath |
| author_sort | Abdullah Bawazir |
| collection | DOAJ |
| description | Abstract Chronic kidney disease (CKD) management has traditionally emphasized dietary protein restriction to slow disease progression and delay end-stage renal disease (ESRD). However, evidence from trials questions the supposed efficacy of this approach and also highlights potential risks such as malnutrition and reduced quality of life. This review discusses the rational for protein restriction in CKD, critiques the existing evidence, and advocates for personalized care that focuses on nutritional adequacy and effective pharmacotherapy. Important advances in CKD treatment, including ACE inhibitors, SGLT2 inhibitors, and GLP-1 receptor agonists, are discussed to propose a comprehensive strategy that optimizes patient outcomes. |
| format | Article |
| id | doaj-art-9b0fb73145e340969cf12e5e0f16be7f |
| institution | Kabale University |
| issn | 2175-8239 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj-art-9b0fb73145e340969cf12e5e0f16be7f2025-02-11T07:42:53ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392025-02-0147110.1590/2175-8239-jbn-2024-po03enProtein restriction in CKD: an outdated strategy in the modern eraAbdullah Bawazirhttps://orcid.org/0000-0003-3999-2230Joel M Topfhttps://orcid.org/0000-0002-4697-7787Swapnil Hiremathhttps://orcid.org/0000-0003-0010-3416Abstract Chronic kidney disease (CKD) management has traditionally emphasized dietary protein restriction to slow disease progression and delay end-stage renal disease (ESRD). However, evidence from trials questions the supposed efficacy of this approach and also highlights potential risks such as malnutrition and reduced quality of life. This review discusses the rational for protein restriction in CKD, critiques the existing evidence, and advocates for personalized care that focuses on nutritional adequacy and effective pharmacotherapy. Important advances in CKD treatment, including ACE inhibitors, SGLT2 inhibitors, and GLP-1 receptor agonists, are discussed to propose a comprehensive strategy that optimizes patient outcomes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100601&lng=en&tlng=enRenal InsufficiencyChronicDietary ProteinsMalnutritionQuality of LifeDietary Restrictions |
| spellingShingle | Abdullah Bawazir Joel M Topf Swapnil Hiremath Protein restriction in CKD: an outdated strategy in the modern era Brazilian Journal of Nephrology Renal Insufficiency Chronic Dietary Proteins Malnutrition Quality of Life Dietary Restrictions |
| title | Protein restriction in CKD: an outdated strategy in the modern era |
| title_full | Protein restriction in CKD: an outdated strategy in the modern era |
| title_fullStr | Protein restriction in CKD: an outdated strategy in the modern era |
| title_full_unstemmed | Protein restriction in CKD: an outdated strategy in the modern era |
| title_short | Protein restriction in CKD: an outdated strategy in the modern era |
| title_sort | protein restriction in ckd an outdated strategy in the modern era |
| topic | Renal Insufficiency Chronic Dietary Proteins Malnutrition Quality of Life Dietary Restrictions |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100601&lng=en&tlng=en |
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