Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp

Abstract Essential oils are promising, safe, and eco-friendly alternatives to chemical fungicides. This study aimed to develop an effective biological control agent using Cinnamomum cassia essential oil (CCEO) as potential fungicidal agent against Saccharomyces cerevisiae and Acremonium sp, both iso...

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Main Authors: Fairouz Boubrik, Tahar Boubellouta, Nabil Benyoucef, Yuva Bellik, Lynda Gali, Abdullah Akdoğan, Dmitry E. Kucher, Aleksandra O. Utkina, Olga D. Kucher, Nazih Y. Rebouh
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-94785-6
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author Fairouz Boubrik
Tahar Boubellouta
Nabil Benyoucef
Yuva Bellik
Lynda Gali
Abdullah Akdoğan
Dmitry E. Kucher
Aleksandra O. Utkina
Olga D. Kucher
Nazih Y. Rebouh
author_facet Fairouz Boubrik
Tahar Boubellouta
Nabil Benyoucef
Yuva Bellik
Lynda Gali
Abdullah Akdoğan
Dmitry E. Kucher
Aleksandra O. Utkina
Olga D. Kucher
Nazih Y. Rebouh
author_sort Fairouz Boubrik
collection DOAJ
description Abstract Essential oils are promising, safe, and eco-friendly alternatives to chemical fungicides. This study aimed to develop an effective biological control agent using Cinnamomum cassia essential oil (CCEO) as potential fungicidal agent against Saccharomyces cerevisiae and Acremonium sp, both isolated from natural orange juice. The yield, chemical composition and antifungal activity of CCEO were evaluated. The essential oil was extracted via hydro-distillation, and its composition was analyzed using gas chromatography-mass spectrometry (GC-MS). The antifungal activity was assessed using the disk diffusion agar method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined using microdilution methods. The extraction yield was 2.8%. (E)-cinnamaldehyde was identified as the major compound (37.72%). Inhibition zones ranged from 51 mm to 80 mm against Saccharomyces cerevisiae and from 75 mm to 90 mm against Acremonium sp. Equal MIC and MFC values were recorded for both fungal strains: MIC = MFC = 6.25% against Saccharomyces cerevisiae and MIC = MFC = 3.125% against Acremonium sp. These findings demonstrate for the first time that CCEO could be a promising antifungal agent against the two primary fungal contaminants of fruit products, Saccharomyces cerevisiae and Acremonium sp.
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institution Kabale University
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publishDate 2025-03-01
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spelling doaj-art-9b0d67ce4e0f4dea8666e8e1081d597f2025-08-20T03:41:14ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-94785-6Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium spFairouz Boubrik0Tahar Boubellouta1Nabil Benyoucef2Yuva Bellik3Lynda Gali4Abdullah Akdoğan5Dmitry E. Kucher6Aleksandra O. Utkina7Olga D. Kucher8Nazih Y. Rebouh9Laboratory of Characterization and Valorization of Natural Resources (L.C.V.R), Faculty of Life and Natural Sciences and of Earth and Universe Sciences, Mohamed El Bachir El Ibrahimi UniversityLaboratory of Characterization and Valorization of Natural Resources (L.C.V.R), Faculty of Life and Natural Sciences and of Earth and Universe Sciences, Mohamed El Bachir El Ibrahimi UniversityBIOGEP Laboratory-Ecole Nationale Polytechnique ENP-El-HarrachLaboratory of Characterization and Valorization of Natural Resources (L.C.V.R), Faculty of Life and Natural Sciences and of Earth and Universe Sciences, Mohamed El Bachir El Ibrahimi UniversityBiotechnology Research Center-CRBtChemical Engineering Department, Faculty of Engineering, Pamukkale UniversityDepartment of Environmental Management, Institute of Environmental Engineering, RUDN UniversityDepartment of Environmental Management, Institute of Environmental Engineering, RUDN UniversityDepartment of Environmental Management, Institute of Environmental Engineering, RUDN UniversityDepartment of Environmental Management, Institute of Environmental Engineering, RUDN UniversityAbstract Essential oils are promising, safe, and eco-friendly alternatives to chemical fungicides. This study aimed to develop an effective biological control agent using Cinnamomum cassia essential oil (CCEO) as potential fungicidal agent against Saccharomyces cerevisiae and Acremonium sp, both isolated from natural orange juice. The yield, chemical composition and antifungal activity of CCEO were evaluated. The essential oil was extracted via hydro-distillation, and its composition was analyzed using gas chromatography-mass spectrometry (GC-MS). The antifungal activity was assessed using the disk diffusion agar method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined using microdilution methods. The extraction yield was 2.8%. (E)-cinnamaldehyde was identified as the major compound (37.72%). Inhibition zones ranged from 51 mm to 80 mm against Saccharomyces cerevisiae and from 75 mm to 90 mm against Acremonium sp. Equal MIC and MFC values were recorded for both fungal strains: MIC = MFC = 6.25% against Saccharomyces cerevisiae and MIC = MFC = 3.125% against Acremonium sp. These findings demonstrate for the first time that CCEO could be a promising antifungal agent against the two primary fungal contaminants of fruit products, Saccharomyces cerevisiae and Acremonium sp.https://doi.org/10.1038/s41598-025-94785-6Chemical compositionAntifungal activityCinnamomum cassia essential oilOrange juiceSaccharomyces cerevisiaeAcremonium sp
spellingShingle Fairouz Boubrik
Tahar Boubellouta
Nabil Benyoucef
Yuva Bellik
Lynda Gali
Abdullah Akdoğan
Dmitry E. Kucher
Aleksandra O. Utkina
Olga D. Kucher
Nazih Y. Rebouh
Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp
Scientific Reports
Chemical composition
Antifungal activity
Cinnamomum cassia essential oil
Orange juice
Saccharomyces cerevisiae
Acremonium sp
title Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp
title_full Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp
title_fullStr Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp
title_full_unstemmed Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp
title_short Investigating the chemical composition and antifungal effect of Cinnamomum cassia essential oil against Saccharomyces cerevisiae and Acremonium sp
title_sort investigating the chemical composition and antifungal effect of cinnamomum cassia essential oil against saccharomyces cerevisiae and acremonium sp
topic Chemical composition
Antifungal activity
Cinnamomum cassia essential oil
Orange juice
Saccharomyces cerevisiae
Acremonium sp
url https://doi.org/10.1038/s41598-025-94785-6
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