Randomization in clinical trials with small sample sizes using group sequential designs.

Randomization in clinical trials with small sample sizes using group sequential designs.

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<h4>Background</h4>Group sequential designs, which allow early stopping for efficacy or futility, may benefit from balanced sample sizes at interim and final analyses. This requirement for balance limits the choice of admissible randomization procedures. We investigate if the choice of r...

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Bibliographic Details
Main Authors: Daniel Bodden, Ralf-Dieter Hilgers, Franz König
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325333
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