Gene2role: a role-based gene embedding method for comparative analysis of signed gene regulatory networks

Gene2role: a role-based gene embedding method for comparative analysis of signed gene regulatory networks

Abstract Background Understanding the dynamics of gene regulatory networks (GRNs) across various cellular states is crucial for deciphering the underlying mechanisms governing cell behavior and functionality. However, current comparative analytical methods, which often focus on simple topological in...

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Bibliographic Details
Main Authors: Xin Zeng, Shu Liu, Bowen Liu, Weihang Zhang, Wanzhe Xu, Fujio Toriumi, Kenta Nakai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Bioinformatics
Subjects:
Graph representation learning
Gene module analysis
Gene regulatory network analysis
Online Access:https://doi.org/10.1186/s12859-025-06128-x
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