Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis
Yuqi Hao,1 Lianxin Li,2 Wenting Du,1 Jinshuai Lu1 1Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Endoscopy Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republ...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-02-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/shifting-of-distribution-and-changing-of-antibiotic-resistance-in-gram-peer-reviewed-fulltext-article-IDR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850228905968926720 |
|---|---|
| author | Hao Y Li L Du W Lu J |
| author_facet | Hao Y Li L Du W Lu J |
| author_sort | Hao Y |
| collection | DOAJ |
| description | Yuqi Hao,1 Lianxin Li,2 Wenting Du,1 Jinshuai Lu1 1Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Endoscopy Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Jinshuai Lu, Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China, Email lujinshuai@xjrmyy.comBackground: Gram-negative bacteria are the predominant pathogens responsible for biliary infections; however, the prevalence of Gram-positive bacteria is currently increasing. Investigating the bacterial spectrum and evolving antibiotic resistance patterns of Gram-positive bacteria is crucial for optimizing the management of acute cholangitis, particularly in the context of the global rise in antibiotic resistance.Methods: This retrospective analysis focused on Gram-positive bacteria isolated from the bile of patients undergoing biliary drainage with acute cholangitis at our hospital from January 1, 2018, to March 31, 2024. In total, 342 strains of Gram-positive bacteria were examined.Results: The main Gram-positive bacteria detected included Enterococcus (57.23%), Staphylococcus (23.41%), and Streptococcus (13.01%). The most common species detected were Enterococcus faecium (36.42%), Enterococcus faecalis (14.16%), and Staphylococcus epidermidis (7.80%). Trend analysis revealed a decrease in the proportion of Enterococcus and an increase in Streptococcus. Additionally, the detection rate of methicillin-resistant Staphylococcus (MRS) showed a significant rise. Gram-positive bacteria exhibited high resistance to erythromycin and penicillin but remained highly susceptible to linezolid and vancomycin. Further, resistance to quinolones among Gram-positive bacteria was notably elevated.Conclusion: The bacterial spectrum and antibiotic resistance patterns of Gram-positive bacteria in acute cholangitis have undergone significant changes. Penicillin is not recommended for the treatment of Gram-positive bacterial infections. Antibiotic resistance should be closely monitored when using quinolones. Particular attention is warranted regarding the markedly increasing antibiotic resistance of Enterococcus faecium.Keywords: acute cholangitis, bile culture, gram-positive bacteria, distribution, antibiotic resistance |
| format | Article |
| id | doaj-art-9b0a563858394f5692b20c73bcfcd512 |
| institution | OA Journals |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-9b0a563858394f5692b20c73bcfcd5122025-08-20T02:04:23ZengDove Medical PressInfection and Drug Resistance1178-69732025-02-01Volume 1811871197100637Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute CholangitisHao YLi LDu WLu JYuqi Hao,1 Lianxin Li,2 Wenting Du,1 Jinshuai Lu1 1Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Endoscopy Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Jinshuai Lu, Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China, Email lujinshuai@xjrmyy.comBackground: Gram-negative bacteria are the predominant pathogens responsible for biliary infections; however, the prevalence of Gram-positive bacteria is currently increasing. Investigating the bacterial spectrum and evolving antibiotic resistance patterns of Gram-positive bacteria is crucial for optimizing the management of acute cholangitis, particularly in the context of the global rise in antibiotic resistance.Methods: This retrospective analysis focused on Gram-positive bacteria isolated from the bile of patients undergoing biliary drainage with acute cholangitis at our hospital from January 1, 2018, to March 31, 2024. In total, 342 strains of Gram-positive bacteria were examined.Results: The main Gram-positive bacteria detected included Enterococcus (57.23%), Staphylococcus (23.41%), and Streptococcus (13.01%). The most common species detected were Enterococcus faecium (36.42%), Enterococcus faecalis (14.16%), and Staphylococcus epidermidis (7.80%). Trend analysis revealed a decrease in the proportion of Enterococcus and an increase in Streptococcus. Additionally, the detection rate of methicillin-resistant Staphylococcus (MRS) showed a significant rise. Gram-positive bacteria exhibited high resistance to erythromycin and penicillin but remained highly susceptible to linezolid and vancomycin. Further, resistance to quinolones among Gram-positive bacteria was notably elevated.Conclusion: The bacterial spectrum and antibiotic resistance patterns of Gram-positive bacteria in acute cholangitis have undergone significant changes. Penicillin is not recommended for the treatment of Gram-positive bacterial infections. Antibiotic resistance should be closely monitored when using quinolones. Particular attention is warranted regarding the markedly increasing antibiotic resistance of Enterococcus faecium.Keywords: acute cholangitis, bile culture, gram-positive bacteria, distribution, antibiotic resistancehttps://www.dovepress.com/shifting-of-distribution-and-changing-of-antibiotic-resistance-in-gram-peer-reviewed-fulltext-article-IDRacute cholangitisbile culturegram-positive bacteriadistributionantibiotic resistance |
| spellingShingle | Hao Y Li L Du W Lu J Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis Infection and Drug Resistance acute cholangitis bile culture gram-positive bacteria distribution antibiotic resistance |
| title | Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis |
| title_full | Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis |
| title_fullStr | Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis |
| title_full_unstemmed | Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis |
| title_short | Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis |
| title_sort | shifting of distribution and changing of antibiotic resistance in gram positive bacteria from bile of patients with acute cholangitis |
| topic | acute cholangitis bile culture gram-positive bacteria distribution antibiotic resistance |
| url | https://www.dovepress.com/shifting-of-distribution-and-changing-of-antibiotic-resistance-in-gram-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT haoy shiftingofdistributionandchangingofantibioticresistanceingrampositivebacteriafrombileofpatientswithacutecholangitis AT lil shiftingofdistributionandchangingofantibioticresistanceingrampositivebacteriafrombileofpatientswithacutecholangitis AT duw shiftingofdistributionandchangingofantibioticresistanceingrampositivebacteriafrombileofpatientswithacutecholangitis AT luj shiftingofdistributionandchangingofantibioticresistanceingrampositivebacteriafrombileofpatientswithacutecholangitis |