Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report
Acute undiffentiated leukemia (AUL) is an acute leukemia with no more than one membrane marker of any given lineage. Blasts often express HLA-DR, CD34, and/or CD38 and may be positive for terminal deoxynucleotidyl transferase (TdT). The expression of CD34, HLA-DR, and CD38 has been shown in pro-T-AL...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/230568 |
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| author | Elisa Cannizzo Giovanni Carulli Luigi Del Vecchio Antonio Azzarà Sara Galimberti Virginia Ottaviano Frederic Preffer Mario Petrini |
| author_facet | Elisa Cannizzo Giovanni Carulli Luigi Del Vecchio Antonio Azzarà Sara Galimberti Virginia Ottaviano Frederic Preffer Mario Petrini |
| author_sort | Elisa Cannizzo |
| collection | DOAJ |
| description | Acute undiffentiated leukemia (AUL) is an acute leukemia with no more than one membrane marker of any given lineage. Blasts often express HLA-DR, CD34, and/or CD38 and may be positive for terminal deoxynucleotidyl transferase (TdT). The expression of CD34, HLA-DR, and CD38 has been shown in pro-T-ALL, although in this case, blasts should also express CD7 and cyCD3. However, some cases of T-ALL without CD3 in the cytoplasm and all TCR chain genes in germ line configuration are reported, features that fit well with a very early hematopoietic cell. We report a case of acute leukemia CD34+/−HLADR+CD7+CD38+cyCD3− in which a diagnosis of AUL was considered. However the blasts were also positive for CD99 and TCR delta gene rearrangement which was found on molecular studies. Therefore a differential diagnosis between AUL and an early cyCD3 negative T-ALL was debated. |
| format | Article |
| id | doaj-art-9b0708bd6ab54dfa9e8de1d52de4383c |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-9b0708bd6ab54dfa9e8de1d52de4383c2025-08-20T02:20:27ZengWileyCase Reports in Hematology2090-65602090-65792011-01-01201110.1155/2011/230568230568Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case ReportElisa Cannizzo0Giovanni Carulli1Luigi Del Vecchio2Antonio Azzarà3Sara Galimberti4Virginia Ottaviano5Frederic Preffer6Mario Petrini7Division of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, 56126 Pisa, ItalyDivision of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Biochemistry and Medical Biotechnology, CEINGE Institute, Federico II University, 80145 Naples, ItalyDivision of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, 56126 Pisa, ItalyDivision of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, 56126 Pisa, ItalyDivision of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USADivision of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, 56126 Pisa, ItalyAcute undiffentiated leukemia (AUL) is an acute leukemia with no more than one membrane marker of any given lineage. Blasts often express HLA-DR, CD34, and/or CD38 and may be positive for terminal deoxynucleotidyl transferase (TdT). The expression of CD34, HLA-DR, and CD38 has been shown in pro-T-ALL, although in this case, blasts should also express CD7 and cyCD3. However, some cases of T-ALL without CD3 in the cytoplasm and all TCR chain genes in germ line configuration are reported, features that fit well with a very early hematopoietic cell. We report a case of acute leukemia CD34+/−HLADR+CD7+CD38+cyCD3− in which a diagnosis of AUL was considered. However the blasts were also positive for CD99 and TCR delta gene rearrangement which was found on molecular studies. Therefore a differential diagnosis between AUL and an early cyCD3 negative T-ALL was debated.http://dx.doi.org/10.1155/2011/230568 |
| spellingShingle | Elisa Cannizzo Giovanni Carulli Luigi Del Vecchio Antonio Azzarà Sara Galimberti Virginia Ottaviano Frederic Preffer Mario Petrini Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report Case Reports in Hematology |
| title | Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report |
| title_full | Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report |
| title_fullStr | Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report |
| title_full_unstemmed | Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report |
| title_short | Prethymic Cytoplasmic CD3 Negative Acute Lymphoblastic Leukemia or Acute Undifferentiated Leukemia: A Case Report |
| title_sort | prethymic cytoplasmic cd3 negative acute lymphoblastic leukemia or acute undifferentiated leukemia a case report |
| url | http://dx.doi.org/10.1155/2011/230568 |
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