Curcumin inhibits cancer progression through regulating expression of microRNAs
Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulatio...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-02-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317691680 |
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| _version_ | 1849250851257843712 |
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| author | Siying Zhou Sijie Zhang Hongyu Shen Wei Chen Hanzi Xu Xiu Chen Dawei Sun Shanliang Zhong Jianhua Zhao Jinhai Tang |
| author_facet | Siying Zhou Sijie Zhang Hongyu Shen Wei Chen Hanzi Xu Xiu Chen Dawei Sun Shanliang Zhong Jianhua Zhao Jinhai Tang |
| author_sort | Siying Zhou |
| collection | DOAJ |
| description | Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. It has been reported that microRNAs as small noncoding RNA molecules are related to cancer progression, which can be regulated by curcumin. Dysregulated microRNAs play vital roles in tumor biology via regulating expressions of target genes and then influencing multiple cancer-related signaling pathways. In this review, we focused on the inhibition effect of curcumin on various cancer progression by regulating expression of multiple microRNAs. Curcumin-induced dysregulation of microRNAs may activate or inactivate a set of signaling pathways, such as Akt, Bcl-2, PTEN, p53, Notch, and Erbb signaling pathways. A better understanding of the relation between curcumin and microRNAs may provide a potential therapeutic target for various cancers. |
| format | Article |
| id | doaj-art-9b0077c918cc4a8dbe2c68536ad65eb4 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-9b0077c918cc4a8dbe2c68536ad65eb42025-08-20T03:57:08ZengSAGE PublishingTumor Biology1423-03802017-02-013910.1177/1010428317691680Curcumin inhibits cancer progression through regulating expression of microRNAsSiying Zhou0Sijie Zhang1Hongyu Shen2Wei Chen3Hanzi Xu4Xiu Chen5Dawei Sun6Shanliang Zhong7Jianhua Zhao8Jinhai Tang9Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, ChinaDepartment of Breath Internal Medicine, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, ChinaThe Fourth Clinical School of Nanjing Medical University, Nanjing, ChinaGraduate School, Xuzhou Medical College, Xuzhou, ChinaDepartment of Radiotherapy, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, ChinaThe Fourth Clinical School of Nanjing Medical University, Nanjing, ChinaDepartment of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, ChinaCenter of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaCenter of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaJiangsu Province Hospital, Nanjing, ChinaCurcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. It has been reported that microRNAs as small noncoding RNA molecules are related to cancer progression, which can be regulated by curcumin. Dysregulated microRNAs play vital roles in tumor biology via regulating expressions of target genes and then influencing multiple cancer-related signaling pathways. In this review, we focused on the inhibition effect of curcumin on various cancer progression by regulating expression of multiple microRNAs. Curcumin-induced dysregulation of microRNAs may activate or inactivate a set of signaling pathways, such as Akt, Bcl-2, PTEN, p53, Notch, and Erbb signaling pathways. A better understanding of the relation between curcumin and microRNAs may provide a potential therapeutic target for various cancers.https://doi.org/10.1177/1010428317691680 |
| spellingShingle | Siying Zhou Sijie Zhang Hongyu Shen Wei Chen Hanzi Xu Xiu Chen Dawei Sun Shanliang Zhong Jianhua Zhao Jinhai Tang Curcumin inhibits cancer progression through regulating expression of microRNAs Tumor Biology |
| title | Curcumin inhibits cancer progression through regulating expression of microRNAs |
| title_full | Curcumin inhibits cancer progression through regulating expression of microRNAs |
| title_fullStr | Curcumin inhibits cancer progression through regulating expression of microRNAs |
| title_full_unstemmed | Curcumin inhibits cancer progression through regulating expression of microRNAs |
| title_short | Curcumin inhibits cancer progression through regulating expression of microRNAs |
| title_sort | curcumin inhibits cancer progression through regulating expression of micrornas |
| url | https://doi.org/10.1177/1010428317691680 |
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