Comparison of trastuzumab deruxtecan and sacituzumab govitecan in HER2-negative metastatic breast cancer: a large real-world data analysis

Abstract Background Trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) are antibody-drug conjugates (ADCs) increasingly used in HER2-negative breast cancer. We hypothesized that treatment benefit would vary across HER2-null, HER2-ultra-low, and HER2-low subgroups of HER2-negative breast c...

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Bibliographic Details
Main Authors: George W. Jr. Sledge, Joanne Xiu, Jeffrey Peter Solzak, Jennifer Ribeiro, Reshma L. Mahtani, Maryam B. Lustberg, Matthew J. Oberley, Milan Radovich, David Spetzler
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Breast Cancer Research
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Online Access:https://doi.org/10.1186/s13058-025-02094-7
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