Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model
Black garlic, a fermented product of fresh garlic, has shown promising potential as a culinary ingredient and a medicinal remedy. This study examined the microbiological makeup, nutritional profile, and health advantages of black garlic to better understand its health-endorsing properties. <i>...
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MDPI AG
2025-04-01
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| Series: | Fermentation |
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| author | Mavra Javed Waqas Ahmed Azmat Ullah Imtiaz Rabbani |
| author_facet | Mavra Javed Waqas Ahmed Azmat Ullah Imtiaz Rabbani |
| author_sort | Mavra Javed |
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| description | Black garlic, a fermented product of fresh garlic, has shown promising potential as a culinary ingredient and a medicinal remedy. This study examined the microbiological makeup, nutritional profile, and health advantages of black garlic to better understand its health-endorsing properties. <i>Thermus</i>, <i>Corynebacterium</i>, <i>Streptococcus</i>, and <i>Brevundimonas</i> were among the prominent taxa found when the microbial diversity in black garlic samples was investigated using Illumina MiSeq sequencing. This provided insight into the complex interactions between microorganisms during the fermentation process and clarified the distinctive qualities of black garlic. This study expanded its scope to include black garlic’s therapeutic potential, specifically in relation to liver function and hangovers caused by alcohol, in addition to its microbial complexity. Significant liver damage was revealed in alcohol-treated rats by serum biochemical indicators and histological stains; this damage was lessened by the administration of black garlic, particularly at higher dosages. Furthermore, black garlic showed hepatoprotective effects attributed to its high phenolic and flavonoid contents. These results offer a novel understanding of the medicinal qualities of black garlic as they lay out possibilities for the creation of functional drugs to treat alcohol-induced liver damage. Conclusively, black garlic’s diverse microbial composition also advances our knowledge of its nutritional makeup and health advantages. In summary, this research highlights the potential of black garlic as a flexible medical tool, having implications for both gastronomic and therapeutic uses. |
| format | Article |
| id | doaj-art-9afdfdcdd5f94407b466c6846e9f184a |
| institution | DOAJ |
| issn | 2311-5637 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Fermentation |
| spelling | doaj-art-9afdfdcdd5f94407b466c6846e9f184a2025-08-20T03:14:42ZengMDPI AGFermentation2311-56372025-04-0111524010.3390/fermentation11050240Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal ModelMavra Javed0Waqas Ahmed1Azmat Ullah2Imtiaz Rabbani3Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore 54000, PakistanDepartment of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanBlack garlic, a fermented product of fresh garlic, has shown promising potential as a culinary ingredient and a medicinal remedy. This study examined the microbiological makeup, nutritional profile, and health advantages of black garlic to better understand its health-endorsing properties. <i>Thermus</i>, <i>Corynebacterium</i>, <i>Streptococcus</i>, and <i>Brevundimonas</i> were among the prominent taxa found when the microbial diversity in black garlic samples was investigated using Illumina MiSeq sequencing. This provided insight into the complex interactions between microorganisms during the fermentation process and clarified the distinctive qualities of black garlic. This study expanded its scope to include black garlic’s therapeutic potential, specifically in relation to liver function and hangovers caused by alcohol, in addition to its microbial complexity. Significant liver damage was revealed in alcohol-treated rats by serum biochemical indicators and histological stains; this damage was lessened by the administration of black garlic, particularly at higher dosages. Furthermore, black garlic showed hepatoprotective effects attributed to its high phenolic and flavonoid contents. These results offer a novel understanding of the medicinal qualities of black garlic as they lay out possibilities for the creation of functional drugs to treat alcohol-induced liver damage. Conclusively, black garlic’s diverse microbial composition also advances our knowledge of its nutritional makeup and health advantages. In summary, this research highlights the potential of black garlic as a flexible medical tool, having implications for both gastronomic and therapeutic uses.https://www.mdpi.com/2311-5637/11/5/240fermented garlicalcoholliverantioxidantblood profilemetagenomics |
| spellingShingle | Mavra Javed Waqas Ahmed Azmat Ullah Imtiaz Rabbani Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model Fermentation fermented garlic alcohol liver antioxidant blood profile metagenomics |
| title | Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model |
| title_full | Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model |
| title_fullStr | Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model |
| title_full_unstemmed | Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model |
| title_short | Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model |
| title_sort | exploring the nutritional profiling and therapeutic effect of fermented garlic on alcohol induced liver injury in animal model |
| topic | fermented garlic alcohol liver antioxidant blood profile metagenomics |
| url | https://www.mdpi.com/2311-5637/11/5/240 |
| work_keys_str_mv | AT mavrajaved exploringthenutritionalprofilingandtherapeuticeffectoffermentedgarliconalcoholinducedliverinjuryinanimalmodel AT waqasahmed exploringthenutritionalprofilingandtherapeuticeffectoffermentedgarliconalcoholinducedliverinjuryinanimalmodel AT azmatullah exploringthenutritionalprofilingandtherapeuticeffectoffermentedgarliconalcoholinducedliverinjuryinanimalmodel AT imtiazrabbani exploringthenutritionalprofilingandtherapeuticeffectoffermentedgarliconalcoholinducedliverinjuryinanimalmodel |