eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis
Aim: Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFRCystatin C), and the difference between Cystatin C and creatinine based eGFR (eGFRdiff) has been suggested to be associated with cardiovascular disease. However, the association between eGFRCystatin C,eGFRdiff and heart fa...
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Elsevier
2024-12-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487524001028 |
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| author | Zhiyu Gu Rui Zhang Weihong Chang Hongxuan Fan Zixuan Dou Peng Liu Aman Liu Boda Zhou |
| author_facet | Zhiyu Gu Rui Zhang Weihong Chang Hongxuan Fan Zixuan Dou Peng Liu Aman Liu Boda Zhou |
| author_sort | Zhiyu Gu |
| collection | DOAJ |
| description | Aim: Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFRCystatin C), and the difference between Cystatin C and creatinine based eGFR (eGFRdiff) has been suggested to be associated with cardiovascular disease. However, the association between eGFRCystatin C,eGFRdiff and heart failure (HF) risk has not been elucidated in a relatively healthy cohort. Methods: We used cohort study data from the NHANES 2001–2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFRCystatin C & eGFRdiff, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. Inverse variance weighted (IVW) was applied in MR study. Results: The cohort study included 2155 participants. Importantly, we simplified eGFRdiff classification into ≥0 and < 0, and found that eGFRdiff≥0 was associated with 52 % reduction of HF risk (OR 0.48, [95 % CI, 0.29–0.80], p = 0.005). We also found that 1 ml/min/1.73 m2 of eGFRCystatin C had a significant negative association with HF after adjusting for covariates. Interestingly, we showed a non-linear association between eGFRCystatin C and HF, eGFRdiff and HF. In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFRCystatin C or low eGFRdiff groups showed significantly poorer survival. Moreover, MR analysis found genetic predisposition to cystatin C was significantly associated with an increased risk of HF. Conclusion: Both decreased eGFRCystatin C and eGFRdiff levels were associated with heart failure and poor survival, but the latter seems more obvious. |
| format | Article |
| id | doaj-art-9afd6a0718894c0fb3691b21e5231f3d |
| institution | OA Journals |
| issn | 2772-4875 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj-art-9afd6a0718894c0fb3691b21e5231f3d2025-08-20T01:54:15ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752024-12-012320033710.1016/j.ijcrp.2024.200337eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysisZhiyu Gu0Rui Zhang1Weihong Chang2Hongxuan Fan3Zixuan Dou4Peng Liu5Aman Liu6Boda Zhou7Institute for Immunology, School of Medicine, Tsinghua University, Beijing, 100084, ChinaDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China; School of Clinical Medicine, Tsinghua University, Beijing, 102218, ChinaDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China; School of Clinical Medicine, Tsinghua University, Beijing, 102218, ChinaDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China; School of Clinical Medicine, Tsinghua University, Beijing, 102218, ChinaSchool of Medicine, Tsinghua University, Beijing, 10084, ChinaDepartment of Cardiology, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, 23 Yijinhuoluo West Street, Dongsheng District, Inner Mongolia, 017000, ChinaDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China; School of Clinical Medicine, Tsinghua University, Beijing, 102218, ChinaDepartment of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China; Corresponding author. Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 168 Litang Road, Changping District, Beijing, 102218, China.Aim: Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFRCystatin C), and the difference between Cystatin C and creatinine based eGFR (eGFRdiff) has been suggested to be associated with cardiovascular disease. However, the association between eGFRCystatin C,eGFRdiff and heart failure (HF) risk has not been elucidated in a relatively healthy cohort. Methods: We used cohort study data from the NHANES 2001–2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFRCystatin C & eGFRdiff, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. Inverse variance weighted (IVW) was applied in MR study. Results: The cohort study included 2155 participants. Importantly, we simplified eGFRdiff classification into ≥0 and < 0, and found that eGFRdiff≥0 was associated with 52 % reduction of HF risk (OR 0.48, [95 % CI, 0.29–0.80], p = 0.005). We also found that 1 ml/min/1.73 m2 of eGFRCystatin C had a significant negative association with HF after adjusting for covariates. Interestingly, we showed a non-linear association between eGFRCystatin C and HF, eGFRdiff and HF. In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFRCystatin C or low eGFRdiff groups showed significantly poorer survival. Moreover, MR analysis found genetic predisposition to cystatin C was significantly associated with an increased risk of HF. Conclusion: Both decreased eGFRCystatin C and eGFRdiff levels were associated with heart failure and poor survival, but the latter seems more obvious.http://www.sciencedirect.com/science/article/pii/S2772487524001028Heart failureCystatin CeGFRNational health and nutrition examination surveyMendelian randomization |
| spellingShingle | Zhiyu Gu Rui Zhang Weihong Chang Hongxuan Fan Zixuan Dou Peng Liu Aman Liu Boda Zhou eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis International Journal of Cardiology. Cardiovascular Risk and Prevention Heart failure Cystatin C eGFR National health and nutrition examination survey Mendelian randomization |
| title | eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis |
| title_full | eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis |
| title_fullStr | eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis |
| title_full_unstemmed | eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis |
| title_short | eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis |
| title_sort | egfrcystatin c difference between egfrcystatin c and egfrcre and heart failure insight from the nhanes 2001 2002 and mendelian randomization analysis |
| topic | Heart failure Cystatin C eGFR National health and nutrition examination survey Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S2772487524001028 |
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