Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective
The largest universal immunization in history has occurred as a result of the COVID-19 pandemic. The developed COVID-19 vaccines have been shown to provide protection against severe forms of COVID-19 by inducing anti-spike neutralizing antibodies. It has been found that individuals who have not been...
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Shiraz University of Medical Sciences
2025-06-01
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| Series: | Journal of Biomedical Physics and Engineering |
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| Online Access: | https://jbpe.sums.ac.ir/article_49625_b0528f4219b30824b5dede7f6cab0bf9.pdf |
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| author | Seyed Ali Reza Mortazavi Abdollah Jafarzadeh Abdolkarim Ghadimi-Moghadam Seyed Mohammad Javad Mortazavi Masoud Haghani Ali Ghadimi-Moghadam Lembit Sihver |
| author_facet | Seyed Ali Reza Mortazavi Abdollah Jafarzadeh Abdolkarim Ghadimi-Moghadam Seyed Mohammad Javad Mortazavi Masoud Haghani Ali Ghadimi-Moghadam Lembit Sihver |
| author_sort | Seyed Ali Reza Mortazavi |
| collection | DOAJ |
| description | The largest universal immunization in history has occurred as a result of the COVID-19 pandemic. The developed COVID-19 vaccines have been shown to provide protection against severe forms of COVID-19 by inducing anti-spike neutralizing antibodies. It has been found that individuals who have not been vaccinated against COVID-19 were more likely to contract the virus during a period when the Delta variant was dominant, as compared to those who have received the complete dose of the vaccine, irrespective of the variant. However, there is no notable disparity in the likelihood of hospitalization, requirement for mechanical ventilation, or mortality between the two groups once infected. Nevertheless, those who are unvaccinated may require additional oxygen support. There are reports indicating unfavorable health effects, ranging from transient thyroid dysfunction to death following vaccination. In addition, some people are susceptible to SARS-CoV-2 infection despite they have immunized with the COVID-19 vaccine. Given all these considerations, several key factors should be better understood and considered to enable us to even more successfully manage future pandemics breakthrough infections. The effectiveness of physical treatment methods, e.g., Low Dose Radiation Therapy (LDRT) should be compared to pharmacological treatments. |
| format | Article |
| id | doaj-art-9af84c9b4e754f2fa2be9887fb82e8f2 |
| institution | DOAJ |
| issn | 2251-7200 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Biomedical Physics and Engineering |
| spelling | doaj-art-9af84c9b4e754f2fa2be9887fb82e8f22025-08-20T03:11:14ZengShiraz University of Medical SciencesJournal of Biomedical Physics and Engineering2251-72002025-06-0115329930610.31661/jbpe.v0i0.2212-157749625Breakthrough Infection and Death after COVID-19 Vaccination: A Physics PerspectiveSeyed Ali Reza Mortazavi0Abdollah Jafarzadeh1Abdolkarim Ghadimi-Moghadam2Seyed Mohammad Javad Mortazavi3Masoud Haghani4Ali Ghadimi-Moghadam5Lembit Sihver6MVLS College, The University of Glasgow, Glasgow, Scotland, UKDepartment of Immunology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IranYasuj University of Medical Sciences, Yasuj, IranDepartment of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, IranFaculty of Medicine, Szeged University, Szeged, HungaryDepartment of Informatics and Engineering Systems, College of Engineering and Computer Science, University of Texas Rio Grande Valley, TX, USAThe largest universal immunization in history has occurred as a result of the COVID-19 pandemic. The developed COVID-19 vaccines have been shown to provide protection against severe forms of COVID-19 by inducing anti-spike neutralizing antibodies. It has been found that individuals who have not been vaccinated against COVID-19 were more likely to contract the virus during a period when the Delta variant was dominant, as compared to those who have received the complete dose of the vaccine, irrespective of the variant. However, there is no notable disparity in the likelihood of hospitalization, requirement for mechanical ventilation, or mortality between the two groups once infected. Nevertheless, those who are unvaccinated may require additional oxygen support. There are reports indicating unfavorable health effects, ranging from transient thyroid dysfunction to death following vaccination. In addition, some people are susceptible to SARS-CoV-2 infection despite they have immunized with the COVID-19 vaccine. Given all these considerations, several key factors should be better understood and considered to enable us to even more successfully manage future pandemics breakthrough infections. The effectiveness of physical treatment methods, e.g., Low Dose Radiation Therapy (LDRT) should be compared to pharmacological treatments.https://jbpe.sums.ac.ir/article_49625_b0528f4219b30824b5dede7f6cab0bf9.pdfcovid-19sars-cov-2vaccinescytokine stormmedical physics |
| spellingShingle | Seyed Ali Reza Mortazavi Abdollah Jafarzadeh Abdolkarim Ghadimi-Moghadam Seyed Mohammad Javad Mortazavi Masoud Haghani Ali Ghadimi-Moghadam Lembit Sihver Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective Journal of Biomedical Physics and Engineering covid-19 sars-cov-2 vaccines cytokine storm medical physics |
| title | Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective |
| title_full | Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective |
| title_fullStr | Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective |
| title_full_unstemmed | Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective |
| title_short | Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective |
| title_sort | breakthrough infection and death after covid 19 vaccination a physics perspective |
| topic | covid-19 sars-cov-2 vaccines cytokine storm medical physics |
| url | https://jbpe.sums.ac.ir/article_49625_b0528f4219b30824b5dede7f6cab0bf9.pdf |
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