Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension
Aim. During enalapril therapy in essential arterial hypertension (EAH) patients, to assess correction of the factors determining arterial thrombosis and inflammatory changes in arterial wall. Material and methods. The study included 21 males with Stage II EAH. The authors analyzed cardiac ultrasound...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2005-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1037 |
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| author | O. M. Moiseeva O. A. Berkovich S. V. Villevalde I. V. Emelyanov |
| author_facet | O. M. Moiseeva O. A. Berkovich S. V. Villevalde I. V. Emelyanov |
| author_sort | O. M. Moiseeva |
| collection | DOAJ |
| description | Aim. During enalapril therapy in essential arterial hypertension (EAH) patients, to assess correction of the factors determining arterial thrombosis and inflammatory changes in arterial wall. Material and methods. The study included 21 males with Stage II EAH. The authors analyzed cardiac ultrasound data, blood rheology, white blood cell (WBC) functional activity, plasma levels of von Willebrand factor (vWF) and intercellular adhesion molecules (ICAM). The second examination was performed after 24-week enalapril therapy (10-40 mg/d). Results. Enalapril therapy was associated with blood rheology improvement, WBC functional activity decrease, decline in vWF and ICAM plasma levels. Enalapril antihypertensive effect was combined with left ventricular hypertrophy (LVH) regression. Conclusion. In EAH patients, long-term enalapril therapy was associated with LVH regression, thrombo- and atherogenesis suppression. |
| format | Article |
| id | doaj-art-9af4d592ff344efcb3dba67adfd1832e |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2005-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-9af4d592ff344efcb3dba67adfd1832e2025-08-20T02:55:48Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252005-12-0146, ч.II3237750Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertensionO. M. Moiseeva0O. A. Berkovich1S. V. Villevalde2I. V. Emelyanov3V.A. Almazov Research Institute of Cardiology, Federal Agency for Health and Social Development, St. PetersburgV.A. Almazov Research Institute of Cardiology, Federal Agency for Health and Social Development, St. PetersburgV.A. Almazov Research Institute of Cardiology, Federal Agency for Health and Social Development, St. PetersburgV.A. Almazov Research Institute of Cardiology, Federal Agency for Health and Social Development, St. PetersburgAim. During enalapril therapy in essential arterial hypertension (EAH) patients, to assess correction of the factors determining arterial thrombosis and inflammatory changes in arterial wall. Material and methods. The study included 21 males with Stage II EAH. The authors analyzed cardiac ultrasound data, blood rheology, white blood cell (WBC) functional activity, plasma levels of von Willebrand factor (vWF) and intercellular adhesion molecules (ICAM). The second examination was performed after 24-week enalapril therapy (10-40 mg/d). Results. Enalapril therapy was associated with blood rheology improvement, WBC functional activity decrease, decline in vWF and ICAM plasma levels. Enalapril antihypertensive effect was combined with left ventricular hypertrophy (LVH) regression. Conclusion. In EAH patients, long-term enalapril therapy was associated with LVH regression, thrombo- and atherogenesis suppression.https://cardiovascular.elpub.ru/jour/article/view/1037essential arterial hypertensionblood cell functional activityendothelial dysfunctionenalapril |
| spellingShingle | O. M. Moiseeva O. A. Berkovich S. V. Villevalde I. V. Emelyanov Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension Кардиоваскулярная терапия и профилактика essential arterial hypertension blood cell functional activity endothelial dysfunction enalapril |
| title | Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension |
| title_full | Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension |
| title_fullStr | Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension |
| title_full_unstemmed | Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension |
| title_short | Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension |
| title_sort | enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension |
| topic | essential arterial hypertension blood cell functional activity endothelial dysfunction enalapril |
| url | https://cardiovascular.elpub.ru/jour/article/view/1037 |
| work_keys_str_mv | AT ommoiseeva enalapriltherapyandthromboticandinflammatoryabnormalitiesinessentialarterialhypertension AT oaberkovich enalapriltherapyandthromboticandinflammatoryabnormalitiesinessentialarterialhypertension AT svvillevalde enalapriltherapyandthromboticandinflammatoryabnormalitiesinessentialarterialhypertension AT ivemelyanov enalapriltherapyandthromboticandinflammatoryabnormalitiesinessentialarterialhypertension |