A review of current developments in RNA modifications in lung cancer
Abstract Lung cancer has the highest incidence and mortality rates worldwide and is the primary cause of cancer-related death. Despite the rapid development of diagnostic methods and targeted drugs in recent years, many lung cancer patients do not benefit from effective therapies. The emergence of d...
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| Format: | Article |
| Language: | English |
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BMC
2024-10-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-024-03528-6 |
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| author | Shujun Zhang Yafeng Liu Kaijie Liu Xinjun Hu Xinyu Gu |
| author_facet | Shujun Zhang Yafeng Liu Kaijie Liu Xinjun Hu Xinyu Gu |
| author_sort | Shujun Zhang |
| collection | DOAJ |
| description | Abstract Lung cancer has the highest incidence and mortality rates worldwide and is the primary cause of cancer-related death. Despite the rapid development of diagnostic methods and targeted drugs in recent years, many lung cancer patients do not benefit from effective therapies. The emergence of drug resistance has led to a reduction in the therapeutic effectiveness of targeted drugs, highlighting a crucial need to explore novel therapeutic targets. Many studies have found that epigenetic plays an important role in the occurrence of lung cancer. This review describes the biological function of epigenetic RNA modifications, such as m6A, m5C, m7G, and m1A, and recent advancements in their role in the development, progression, and prognosis of lung cancer. This review aims to provide new guidance for the treatment of lung cancer. |
| format | Article |
| id | doaj-art-9af4a6bbb0894e7fba53695481a36a37 |
| institution | OA Journals |
| issn | 1475-2867 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-9af4a6bbb0894e7fba53695481a36a372025-08-20T02:12:03ZengBMCCancer Cell International1475-28672024-10-0124111610.1186/s12935-024-03528-6A review of current developments in RNA modifications in lung cancerShujun Zhang0Yafeng Liu1Kaijie Liu2Xinjun Hu3Xinyu Gu4Department of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyDepartment of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Jianxi DistrictAbstract Lung cancer has the highest incidence and mortality rates worldwide and is the primary cause of cancer-related death. Despite the rapid development of diagnostic methods and targeted drugs in recent years, many lung cancer patients do not benefit from effective therapies. The emergence of drug resistance has led to a reduction in the therapeutic effectiveness of targeted drugs, highlighting a crucial need to explore novel therapeutic targets. Many studies have found that epigenetic plays an important role in the occurrence of lung cancer. This review describes the biological function of epigenetic RNA modifications, such as m6A, m5C, m7G, and m1A, and recent advancements in their role in the development, progression, and prognosis of lung cancer. This review aims to provide new guidance for the treatment of lung cancer.https://doi.org/10.1186/s12935-024-03528-6EpigeneticRNA modificationLung cancerNSCLC |
| spellingShingle | Shujun Zhang Yafeng Liu Kaijie Liu Xinjun Hu Xinyu Gu A review of current developments in RNA modifications in lung cancer Cancer Cell International Epigenetic RNA modification Lung cancer NSCLC |
| title | A review of current developments in RNA modifications in lung cancer |
| title_full | A review of current developments in RNA modifications in lung cancer |
| title_fullStr | A review of current developments in RNA modifications in lung cancer |
| title_full_unstemmed | A review of current developments in RNA modifications in lung cancer |
| title_short | A review of current developments in RNA modifications in lung cancer |
| title_sort | review of current developments in rna modifications in lung cancer |
| topic | Epigenetic RNA modification Lung cancer NSCLC |
| url | https://doi.org/10.1186/s12935-024-03528-6 |
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