Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study
Background: Early identification of determinants of tuberculosis treatment failure is crucial in resource-limited developing countries. Tuberculosis treatment failure is one of the challenges to controlling tuberculosis. However, evidence on the factors contributing to tuberculosis treatment failure...
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Elsevier
2025-03-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398425000259 |
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| author | Nasir Tayib Nur Yadeta Dessie Samuel Demissie Darcho Samrawit Berihun Behailu Hawulte Ayele |
| author_facet | Nasir Tayib Nur Yadeta Dessie Samuel Demissie Darcho Samrawit Berihun Behailu Hawulte Ayele |
| author_sort | Nasir Tayib Nur |
| collection | DOAJ |
| description | Background: Early identification of determinants of tuberculosis treatment failure is crucial in resource-limited developing countries. Tuberculosis treatment failure is one of the challenges to controlling tuberculosis. However, evidence on the factors contributing to tuberculosis treatment failure is limited. Therefore, this study aims to determine the factors contributing to tuberculosis treatment failure. Methods: A retrospective, unmatched case-control study design was conducted by recruiting 264 (53 cases and 211 controls) at public health facilities. Cases were patients with pulmonary tuberculosis with a tuberculosis treatment outcome registered as treatment failure. Controls were patients with pulmonary tuberculosis with tuberculosis treatment outcomes registered as cured and treatment completed during anti-tuberculosis treatment. Result: 264 records (53 cases and 211 controls) were included from tuberculosis registers. In the current study, determinants of tuberculosis treatment failure were being male (AOR = 4.06, 95 % CI: 1.65, 9.75), age 30–40 years (AOR = 0.24, 95 % CI: 0.10, 0.54), receiving directly observed therapy treatment (AOR = 3.94, 95 % CI: 1.63, 9.51), adherence to tuberculosis medication (AOR = 7.56, 95 % CI: 2.70, 20.78), being treated at a hospital (AOR = 11.89, 95 % CI: 3.80, 33.79), and being HIV positive (AOR = 4.783, 95 % CI: 1.46, 15.65). (Table 4) Conclusions: This study found that the rate of tuberculosis treatment failure among adult patients with pulmonary tuberculosis was relatively lower in Eastern Ethiopia. Targeted interventions should be implemented to address the identified risk factors, particularly among high-risk groups, to improve tuberculosis treatment outcomes throughout the treatment process. |
| format | Article |
| id | doaj-art-9af2e5b275e54048a56b6a4062477c47 |
| institution | Kabale University |
| issn | 2213-3984 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj-art-9af2e5b275e54048a56b6a4062477c472025-01-20T04:17:26ZengElsevierClinical Epidemiology and Global Health2213-39842025-03-0132101936Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control studyNasir Tayib Nur0Yadeta Dessie1Samuel Demissie Darcho2Samrawit Berihun3Behailu Hawulte Ayele4Department of Veterinary Medicine of Qabridahar University, Qabridahar, EthiopiaSchool of Public Health College of Medicine and Health Science, Haramaya University, Harar, EthiopiaSchool of Public Health College of Medicine and Health Science, Haramaya University, Harar, Ethiopia; Corresponding author. School of Public Health College of Health and Medical Sciences, Haramaya University, P.O. Box, 235, Harar, Ethiopia.School of Public Health College of Medicine and Health Science, Haramaya University, Harar, EthiopiaSchool of Public Health College of Medicine and Health Science, Haramaya University, Harar, EthiopiaBackground: Early identification of determinants of tuberculosis treatment failure is crucial in resource-limited developing countries. Tuberculosis treatment failure is one of the challenges to controlling tuberculosis. However, evidence on the factors contributing to tuberculosis treatment failure is limited. Therefore, this study aims to determine the factors contributing to tuberculosis treatment failure. Methods: A retrospective, unmatched case-control study design was conducted by recruiting 264 (53 cases and 211 controls) at public health facilities. Cases were patients with pulmonary tuberculosis with a tuberculosis treatment outcome registered as treatment failure. Controls were patients with pulmonary tuberculosis with tuberculosis treatment outcomes registered as cured and treatment completed during anti-tuberculosis treatment. Result: 264 records (53 cases and 211 controls) were included from tuberculosis registers. In the current study, determinants of tuberculosis treatment failure were being male (AOR = 4.06, 95 % CI: 1.65, 9.75), age 30–40 years (AOR = 0.24, 95 % CI: 0.10, 0.54), receiving directly observed therapy treatment (AOR = 3.94, 95 % CI: 1.63, 9.51), adherence to tuberculosis medication (AOR = 7.56, 95 % CI: 2.70, 20.78), being treated at a hospital (AOR = 11.89, 95 % CI: 3.80, 33.79), and being HIV positive (AOR = 4.783, 95 % CI: 1.46, 15.65). (Table 4) Conclusions: This study found that the rate of tuberculosis treatment failure among adult patients with pulmonary tuberculosis was relatively lower in Eastern Ethiopia. Targeted interventions should be implemented to address the identified risk factors, particularly among high-risk groups, to improve tuberculosis treatment outcomes throughout the treatment process.http://www.sciencedirect.com/science/article/pii/S2213398425000259DeterminantsTuberculosisTreatment failureSomaliaEastern Ethiopia |
| spellingShingle | Nasir Tayib Nur Yadeta Dessie Samuel Demissie Darcho Samrawit Berihun Behailu Hawulte Ayele Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study Clinical Epidemiology and Global Health Determinants Tuberculosis Treatment failure Somalia Eastern Ethiopia |
| title | Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study |
| title_full | Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study |
| title_fullStr | Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study |
| title_full_unstemmed | Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study |
| title_short | Determinants of tuberculosis treatment failure in public health facilities of Jigjiga Town, Somali Regional State, Ethiopia: A multi-center case-control study |
| title_sort | determinants of tuberculosis treatment failure in public health facilities of jigjiga town somali regional state ethiopia a multi center case control study |
| topic | Determinants Tuberculosis Treatment failure Somalia Eastern Ethiopia |
| url | http://www.sciencedirect.com/science/article/pii/S2213398425000259 |
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