Alkaloids in Tibetan Medicine <i>Corydalis conspersa</i> Maxim. and Their Hepatoprotective Effect Against Acute Liver Injury

Alkaloids in Tibetan Medicine <i>Corydalis conspersa</i> Maxim. and Their Hepatoprotective Effect Against Acute Liver Injury

The aim of the present study was to investigate the alkaloids of Tibetan medicine <i>Corydalis conspersa</i> Maxim. and their hepatoprotective effect against carbon tetrachloride (CCl<sub>4</sub>)-induced acute liver injury (ALI). The ethanol extract of this herbal medicine w...

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Bibliographic Details
Main Authors: Qiu Wang, Yingrui Jin, Fangyan Fan, Xueting Feng, Xuemei Yin, Xiaoling Wang, Zangjia Geng
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
<i>Corydalis conspersa</i> Maxim.
alkaloid
structural identification
Tibetan medicine
acute liver injury
Online Access:https://www.mdpi.com/1420-3049/30/10/2127
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Summary:The aim of the present study was to investigate the alkaloids of Tibetan medicine <i>Corydalis conspersa</i> Maxim. and their hepatoprotective effect against carbon tetrachloride (CCl<sub>4</sub>)-induced acute liver injury (ALI). The ethanol extract of this herbal medicine was subjected to a phytochemical study. Network pharmacology (NP) and molecular docking were used to predict the active constituents and mechanism of action against ALI. Seven alkaloid components were isolated and identified from this herb medicine, including acetylcorynoline (<b>1</b>, ACE), corynoline (<b>2</b>), scoulerine (<b>3</b>), protopine (<b>4</b>), bulbocapnine (<b>5</b>, BBC), palmatine (<b>6</b>), and isocorydine (<b>7</b>, ISO), among which compounds <b>1</b>, <b>3</b>, and <b>5</b> were isolated from this plant for the first time. Pharmacological experiments have shown that compounds <b>1</b>, <b>5</b>, <b>7</b>, and the total alkaloids (TTA) of the plant exhibit good improvement effects on CCl<sub>4</sub>-induced ALI in mice. NP and molecular docking predicted that their mechanism of action may be related to targets such as STAT3, SRC, EGFR, PIK3CA, and HSP90AA1. These research findings provide a theoretical basis for the development of the medicinal value of Tibetan medicine <i>Corydalis conspersa</i> Maxim.
ISSN:1420-3049

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